Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 16/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.37 |
| ▸ | CPB1 | P15086 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979699 | 0.94 | CPB1 (0.39) | S1PR1KDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL1979764 | 0.89 | S1PR1 (0.43) | S1PR1KDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL1980342 | 0.89 | S1PR1 (0.47) | S1PR1KDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL1979741 | 0.89 | S1PR1 (0.36) | S1PR1KDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL1981126 | 0.88 | S1PR1 (0.50) | S1PR1KDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL1982528 | 0.88 | S1PR1 (0.48) | S1PR1LMNAS1PR3 | |
| SCHEMBL1981536 | 0.86 | S1PR1 (0.52) | S1PR1KDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL1980288 | 0.86 | S1PR1 (0.41) | S1PR1KDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL1980539 | 0.86 | S1PR1 (0.41) | S1PR1KDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL1988769 | 0.86 | S1PR1 (0.42) | S1PR1KDM4EALDH1A1SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343287-A1 | New 2-aminothiadiazole derivatives | Almirall, S.A. (ES) | 2011-07-13 | — | — | EP | claimed |
| WO-2011069647-A1 | NEW 2-AMINOTHIADIAZOLE DERIVATIVES | ALMIRALL, S.A. (ES) | 2011-06-16 | — | — | WO | claimed |
| EP-2343287-A1 | New 2-aminothiadiazole derivatives | Almirall, S.A. (ES) | 2011-07-13 | — | — | EP | disclosed |
| WO-2011069647-A1 | NEW 2-AMINOTHIADIAZOLE DERIVATIVES | ALMIRALL, S.A. (ES) | 2011-06-16 | — | — | WO | disclosed |