Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.52 |
| ▸ | TACR3 | P29371 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | PAK4 | O96013 | 2/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PRKCG | P05129 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16679895 | 0.83 | L3MBTL1 (0.53) | HPGDLMNAKDM4EALDH1A1TSHR | |
| SCHEMBL16679897 | 0.83 | L3MBTL1 (0.53) | HPGDLMNAKDM4EALDH1A1TSHR | |
| SCHEMBL5643849 | 0.81 | NPC1 (0.55) | HPGDLMNAKDM4EALDH1A1TSHR | |
| SCHEMBL28015856 | 0.81 | ALDH1A1 (0.60) | HPGDLMNAKDM4EALDH1A1TSHR | |
| SCHEMBL30776214 | 0.81 | HPGD (0.68) | HPGDLMNAKDM4EALDH1A1TSHR | |
| SCHEMBL28693505 | 0.80 | HPGD (0.56) | HPGDLMNAKDM4EALDH1A1HSD17B10 | |
| SCHEMBL8855769 | 0.80 | KDM4E (0.51) | HPGDLMNAKDM4EALDH1A1TSHR | |
| SCHEMBL3311541 | 0.79 | RIPK1 (0.60) | ALDH1A1RIPK1TACR3MAPK1PAK4 | |
| SCHEMBL668277 | 0.79 | RIPK1 (0.60) | ALDH1A1RIPK1TACR3MAPK1PAK4 | |
| SCHEMBL117597 | 0.79 | RIPK1 (0.60) | ALDH1A1RIPK1TACR3MAPK1PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10188649-B2 | Aminoheteroaryl benzamides as kinase inhibitors | NOVARTIS AG (CH) | 2019-01-29 | — | — | US | disclosed |
| US-20180028532-A1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2018-02-01 | — | — | US | disclosed |
| CN-104529796-A | Catalytic synthesis application based on frustrated Lewis acid-base pair | UNIV HUNAN | 2015-04-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10188649-B2 | Aminoheteroaryl benzamides as kinase inhibitors | ABL1, MAP3K12, MAP3K2 | HPGD 3257/4885LMNA 4403/4885KDM4E 657/4885 |
| US-20180028532-A1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | ABL1, MAP3K12, MAP3K2 | HPGD 3257/4885LMNA 4403/4885KDM4E 657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.