SCHEMBL198142

SCHEMBL198142

Nc1ccnc(-c2nccc(N)c2-c2cc(N)ccn2)c1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ASIC3 Q9UHC3 3/20 0.48
KDM4C Q9H3R0 1/20 0.31
NR4A2 P43354 3/20 0.31
SOS2 Q07890 1/20 0.31
NCF1 P14598 1/20 0.31
CCR1 P32246 1/20 0.30
CCR5 P51681 1/20 0.30
CCR8 P51685 1/20 0.30
MEN1 O00255 1/20 0.30
ALDH1A1 P00352 1/20 0.30
LMNA P02545 1/20 0.30
CYP2D6 P10635 1/20 0.30
MAPT P10636 1/20 0.30
CHRM1 P11229 1/20 0.30
TSHR P16473 1/20 0.30
MAPK1 P28482 1/20 0.30
KMT2A Q03164 1/20 0.30
KCNA1 Q09470 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL352526 0.79 ASIC3 (0.47) ASIC3KDM4CNR4A2CCR1CCR5
SCHEMBL314105 0.76 ASIC3 (0.67) ASIC3KDM4CCCR1CCR5CCR8
SCHEMBL1513867 0.74 KDM4E (0.50) CCR1CCR5CCR8ALDH1A1LMNA
SCHEMBL9132675 0.74 ASIC3 (0.64) ASIC3KDM4CCCR1CCR5CCR8
SCHEMBL9151109 0.74 ASIC3 (0.64) ASIC3KDM4CCCR1CCR5CCR8
SCHEMBL9132100 0.74 ASIC3 (0.64) ASIC3KDM4CCCR1CCR5CCR8
SCHEMBL29481117 0.73 ASIC3 (0.41) ASIC3KDM4C
SCHEMBL28593136 0.70 ULK1 (0.46) ASIC3CCR1CCR5CCR8ALDH1A1
SCHEMBL30337333 0.70 ASIC3 (0.79) ASIC3KDM4CCCR1CCR5CCR8
SCHEMBL25250996 0.69 ASIC3 (0.53) ASIC3SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180128767-A1 Small Volume In Vitro Analyte Sensor ABBOTT DIABETES CARE INC. (US) 2018-05-10 US disclosed
US-9891185-B2 Small volume in vitro analyte sensor ABBOTT DIABETES CARE INC. (US) 2018-02-13 US disclosed
US-9662057-B2 Integrated sample acquisition and analyte measurement method ABBOTT DIABETES CARE INC. (US) 2017-05-30 US disclosed
US-20160334356-A1 Small Volume In Vitro Analyte Sensor THERASENSE, INC. 2016-11-17 US disclosed
US-20160235350-A1 Integrated Sample Acquisition and Analyte Measurement Device THERASENSE, INC. 2016-08-18 US disclosed
US-9341591-B2 Small volume in vitro analyte sensor ABBOTT DIABETES CARE INC. (US) 2016-05-17 US disclosed
US-9316609-B2 Small volume in vitro analyte sensor ABBOTT DIABETES CARE INC. (US) 2016-04-19 US disclosed
US-9291592-B2 Small volume in vitro analyte sensor ABBOTT DIABETES CARE INC. (US) 2016-03-22 US disclosed
US-9271669-B2 Method for integrated sample acquisition and analyte measurement device ABBOTT DIABETES CARE INC. (US) 2016-03-01 US disclosed
US-9234863-B2 Small volume in vitro analyte sensor ABBOTT DIABETES CARE INC. (US) 2016-01-12 US disclosed
US-20040060818-A1 Small volume in vitro analyte sensor and methods of making THERASENSE, INC. (US) 2004-04-01 US disclosed
EP-1119637-B1 SMALL VOLUME IN VITRO ANALYTE SENSOR WITH DIFFUSIBLE OR NON-LEACHABLE REDOX MEDIATOR THERASENSE INC (US) 2004-03-24 EP disclosed
US-20040054267-A1 Small volume in vitro analyte sensor THERASENSE, INC. 2004-03-18 US disclosed
US-20030199744-A1 Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator THERASENSE, INC. (US) 2003-10-23 US disclosed
US-6618934-B1 Method of manufacturing small volume in vitro analyte sensor THERASENSE, INC. 2003-09-16 US disclosed
US-6592745-B1 Analytical sensors for the detection of bioanalytes in a small volume sample; to monitor glucose in diabetic patients and lactate during critical care THERASENSE, INC. 2003-07-15 US disclosed
US-6591125-B1 Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator THERASENSE, INC. 2003-07-08 US disclosed
US-6461496-B1 BLOOD GLUCOSE THERASENSE, INC. 2002-10-08 US disclosed
US-6338790-B1 DETECTION OF BIOANALYTES IN A SMALL VOLUME SAMPLE; CONCENTRATION OF A BIOMOLECULE, SUCH AS GLUCOSE OR LACTATE, USING TECHNIQUES SUCH AS COULOMETRY, AMPEROMETRY, AND POTENTIOMETRY. AN ENZYME CAPABLE OF CATALYZING THE THERASENSE, INC. 2002-01-15 US disclosed
US-6299757-B1 ANALYTICAL SENSORS FOR THE DETECTION OF BIOANALYTES; ESPECIALLY MONITORING GLUCOSE LEVELS IN DIABETIC PATIENTS THERASENSE, INC. 2001-10-09 US disclosed