Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2240288 | 0.83 | HTR1A (0.44) | HTR1ADRD2ADRA1AHTR2A | |
| SCHEMBL1922464 | 0.83 | HTR1A (0.44) | HTR1ADRD2ADRA1AHTR2A | |
| SCHEMBL29960150 | 0.82 | MAP3K14 (0.63) | MAP3K14HTR1ACTNNB1WNT3AABCB1 | |
| SCHEMBL29960701 | 0.81 | MAP3K14 (0.45) | MAP3K14HTR1ADRD2CTNNB1WNT3A | |
| Hydrochloric Acid SCHEMBL29960788 | 0.79 | HTR1A (0.54) | MAP3K14HTR1ACTNNB1WNT3AHTR2A | |
| SCHEMBL23841360 | 0.78 | MAP3K14 (0.46) | MAP3K14HTR1ACTNNB1WNT3AABCB1 | |
| SCHEMBL27736686 | 0.78 | MAP3K14 (0.67) | MAP3K14ADRA1AHTR2AAADAT | |
| SCHEMBL4729948 | 0.78 | MAP3K14 (0.67) | MAP3K14ADRA1AHTR2AAADAT | |
| SCHEMBL20480263 | 0.78 | MAP3K14 (0.43) | MAP3K14HTR1ACTNNB1WNT3A | |
| SCHEMBL20480690 | 0.77 | MAP3K14 (0.42) | MAP3K14HTR1ADRD2CTNNB1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180028492-A1 | COMPOUNDS AND COMPOSITIONS AND USES THEREOF | PGI DRUG DISCOVERY LLC | 2018-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180028492-A1 | COMPOUNDS AND COMPOSITIONS AND USES THEREOF | ACHE, CHAT, MAOB | MAP3K14 4105/4885HTR1A 176/4885DRD2 447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.