Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.45 |
| ▸ | AHR | P35869 | 2/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CRHBP | P24387 | 2/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28731754 | 0.81 | CA2 (0.41) | AHRSMN1; SMN2CA2TAAR1HTR5A | |
| SCHEMBL136087 | 0.80 | MAP3K14 (0.46) | MAP3K14AHRITGB2ICAM1ITGAL | |
| SCHEMBL31300318 | 0.79 | MAP3K14 (0.45) | MAP3K14ITGB2ICAM1ITGALADRA2A | |
| SCHEMBL26962672 | 0.79 | MAP3K14 (0.45) | MAP3K14ITGB2ICAM1ITGALADRA2A | |
| SCHEMBL27736686 | 0.79 | MAP3K14 (0.67) | MAP3K14ITGB2ICAM1ITGALADRA2A | |
| SCHEMBL1266237 | 0.79 | MAP3K14 (0.45) | MAP3K14ITGB2ICAM1ITGALADRA2A | |
| SCHEMBL4729948 | 0.79 | MAP3K14 (0.67) | MAP3K14ITGB2ICAM1ITGALADRA2A | |
| SCHEMBL30216657 | 0.79 | MAP3K14 (0.45) | MAP3K14ITGB2ICAM1ITGALADRA2A | |
| Hydrochloric Acid SCHEMBL4654876 | 0.77 | MAP3K14 (0.65) | MAP3K14ITGB2ICAM1ITGALADRA2A | |
| Hydrochloric Acid SCHEMBL26962795 | 0.77 | MAP3K14 (0.44) | MAP3K14ITGB2ICAM1ITGALADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180028492-A1 | COMPOUNDS AND COMPOSITIONS AND USES THEREOF | PGI DRUG DISCOVERY LLC | 2018-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180028492-A1 | COMPOUNDS AND COMPOSITIONS AND USES THEREOF | ACHE, CHAT, MAOB | MAP3K14 4105/4885AHR 1339/4885ITGB2 3885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.