Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.37 |
| ▸ | BCL6 | P41182 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 3/20 | 0.36 |
| ▸ | BTK | Q06187 | 3/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17708203 | 1.00 | EGFR (0.39) | EGFRPRKCQTBK1BCL6CDK1 | |
| SCHEMBL15337712 | 0.93 | BCL6 (0.44) | EGFRPRKCQTBK1BCL6ITK | |
| SCHEMBL19830189 | 0.93 | BCL6 (0.44) | EGFRPRKCQTBK1BCL6ITK | |
| SCHEMBL15337482 | 0.91 | ULK1 (0.40) | EGFRTBK1BCL6CHEK1FLT3 | |
| SCHEMBL15337710 | 0.91 | ULK1 (0.40) | EGFRTBK1BCL6CHEK1FLT3 | |
| SCHEMBL19527806 | 0.91 | ULK1 (0.40) | EGFRTBK1BCL6CHEK1FLT3 | |
| SCHEMBL15337651 | 0.91 | ULK1 (0.40) | EGFRTBK1BCL6CHEK1FLT3 | |
| SCHEMBL15337489 | 0.86 | BCL6 (0.44) | EGFRPRKCQBCL6ITKBTK | |
| SCHEMBL19830190 | 0.85 | ULK1 (0.40) | EGFRPRKCQBCL6ITKBTK | |
| SCHEMBL15337657 | 0.82 | EGFR (0.48) | EGFRPRKCQTBK1BCL6CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005777-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-20180030050-A1 | Protein Kinase C Inhibitors and Uses Thereof | MIDCAP FINANCIAL TRUST | 2018-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10005777-B2 | Protein kinase C inhibitors and uses thereof | PRKCH, PRKCA, PRKCB | EGFR 2299/4885PRKCQ 5/4885TBK1 130/4885 |
| US-20180030050-A1 | Protein Kinase C Inhibitors and Uses Thereof | PRKCH, PRKCA, PRKCB | EGFR 2299/4885PRKCQ 5/4885TBK1 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.