SCHEMBL19831677

SCHEMBL19831677

CC(C)OC(=O)c1cccnc1N(C)C1CCN(Cc2ccccc2)C1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 5/20 0.60
DRD4 P21917 3/20 0.60
DRD3 P35462 3/20 0.60
GMNN O75496 2/20 0.60
ALDH1A1 P00352 2/20 0.60
LMNA P02545 2/20 0.60
HPGD P15428 2/20 0.60
PMP22 Q01453 2/20 0.60
SMN1; SMN2 Q16637 2/20 0.60
TDP1 Q9NUW8 2/20 0.60
CYP2D6 P10635 2/20 0.60
CYP3A4 P08684 2/20 0.60
TP53 P04637 1/20 0.60
HTR2A P28223 3/20 0.50
SIGMAR1 Q99720 3/20 0.50
DRD1 P21728 1/20 0.50
SCN1A P35498 4/20 0.42
SCN8A Q9UQD0 4/20 0.42
HTR2C P28335 2/20 0.42
HTR2B P41595 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12516846 1.00 DRD2 (0.60) DRD2DRD4DRD3GMNNALDH1A1
SCHEMBL12516842 1.00 DRD2 (0.60) DRD2DRD4DRD3GMNNALDH1A1
Hydrochloric Acid SCHEMBL2223967 0.99 DRD2 (0.59) DRD2DRD4DRD3GMNNALDH1A1
Hydrochloric Acid SCHEMBL14632762 0.99 DRD2 (0.59) DRD2DRD4DRD3GMNNALDH1A1
SCHEMBL2223053 0.95 DRD2 (0.54) DRD2DRD4DRD3GMNNALDH1A1
SCHEMBL2225901 0.93 LMNA (0.53) DRD2DRD4DRD3GMNNALDH1A1
SCHEMBL2221522 0.93 DRD2 (0.55) DRD2DRD4DRD3GMNNALDH1A1
SCHEMBL2223452 0.91 LMNA (0.50) DRD2DRD4DRD3GMNNALDH1A1
SCHEMBL2221830 0.91 LMNA (0.53) DRD2DRD4DRD3GMNNALDH1A1
SCHEMBL2223876 0.91 LMNA (0.53) DRD2DRD4DRD3GMNNALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2974730-B1 DRUG FOR RESPIRATORY DISEASES DAIICHI SANKYO CO LTD (JP) 2018-01-31 EP disclosed