Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | OGG1 | O15527 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20445881 | 0.81 | LMNA (0.50) | CES2CES1CA12MMP2CA14 | |
| SCHEMBL7734235 | 0.81 | CES2 (0.56) | CES2CES1CA12MMP2CA14 | |
| SCHEMBL16235219 | 0.78 | LMNA (0.47) | CES2CES1CA12MMP2CA14 | |
| SCHEMBL1440635 | 0.77 | KMT2A (0.43) | CES2CES1CA12MMP2CA14 | |
| SCHEMBL2096724 | 0.76 | GSK3B (0.64) | CES2CES1CA12MMP2CA14 | |
| SCHEMBL28646814 | 0.72 | CES2 (0.52) | CES2CES1CA12MMP2CA14 | |
| SCHEMBL20703078 | 0.72 | CES2 (0.52) | CES2CES1CA12MMP2CA14 | |
| SCHEMBL634337 | 0.72 | CES2 (0.52) | CES2CES1CA12MMP2CA14 | |
| SCHEMBL28636492 | 0.72 | CES2 (0.52) | CES2CES1CA12MMP2CA14 | |
| SCHEMBL29003581 | 0.72 | CES2 (0.56) | CES2CES1CA12MMP2CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2337781-A2 | ANTI-VIRAL COMPOUNDS TO TREAT HCV INFECTION | Abbott Laboratories (US) | 2011-06-29 | — | — | EP | disclosed |
| WO-2010144646-A2 | ANTI-VIRAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2010-12-16 | — | — | WO | disclosed |