Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 4/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.35 |
| ▸ | MERTK | Q12866 | 3/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 3/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1983193 | 1.00 | CHUK (0.46) | CHUKTLR8CHRM3PDE4APDE4B | |
| SCHEMBL1982047 | 0.82 | CHUK (0.46) | CHUKTLR8CHRM3PDE4APDE4B | |
| SCHEMBL1982045 | 0.82 | CHUK (0.46) | CHUKTLR8CHRM3PDE4APDE4B | |
| SCHEMBL395254 | 0.82 | PIK3CA (0.44) | TLR8PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL396024 | 0.77 | TLR8 (0.41) | TLR8MAPK8MAPK9ADORA2AADORA1 | |
| SCHEMBL3733137 | 0.77 | TLR8 (0.41) | TLR8MAPK8MAPK9ADORA2AADORA1 | |
| SCHEMBL19955978 | 0.75 | PDE4A (0.46) | CHUKTLR8CHRM3PDE4APDE4B | |
| SCHEMBL26451093 | 0.75 | PDE4D (0.39) | CHUKTLR8CHRM3PDE4APDE4B | |
| SCHEMBL1984281 | 0.74 | CHUK (0.40) | CHUKCHRM3PDE4APDE4BPDE4C | |
| SCHEMBL8202941 | 0.74 | CHUK (0.40) | CHUKCHRM3PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633204-B2 | 4-methylpyridopyrimidinone compounds | PFIZER INC. (US) | 2014-01-21 | — | — | US | disclosed |
| EP-2074122-B9 | PYRIDO (2, 3-D) PYRIMIDIN0NE COMPOUNDS AND THEIR USE AS PI3 INHIBITORS | PFIZER PROD INC (US) | 2013-09-11 | — | — | EP | disclosed |
| US-20120309775-A1 | 4-METHYLPYRIDOPYRIMIDINONE COMPOUNDS | PFIZER INC (US) | 2012-12-06 | — | — | US | disclosed |
| US-8273755-B2 | 4-methylpyridopyrimidinone compounds | PFIZER INC (US) | 2012-09-25 | — | — | US | disclosed |
| EP-2074122-B1 | PYRIDO (2, 3-D) PYRIMIDIN0NE COMPOUNDS AND THEIR USE AS PI3 INHIBITORS | PFIZER PROD INC (US) | 2011-06-29 | — | — | EP | disclosed |
| US-20100137279-A1 | 4-METHYLPYRIDOPYRIMIDINONE COMPOUNDS | PFIZER INC. (US) | 2010-06-03 | — | — | US | disclosed |
| US-7696213-B2 | 4-methylpyridopyrimidinone compounds | PFIZER INC (US) | 2010-04-13 | — | — | US | disclosed |
| EP-2074122-A1 | PYRIDO (2, 3-D) PYRIMIDIN0NE COMPOUNDS AND THEIR USE AS PI3 INHIBITORS | Pfizer Products Incorporated (US) | 2009-07-01 | — | — | EP | disclosed |
| US-20080090801-A1 | 4-METHYLPYRIDOPYRIMIDINONE COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| WO-2008032162-A1 | PYRIDO (2, 3-D) PYRIMIDIN0NE COMPOUNDS AND THEIR USE AS PI3 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090801-A1 | 4-METHYLPYRIDOPYRIMIDINONE COMPOUNDS | PI4KA, PI4KB, PIK3CA | CHUK 445/4885TLR8 4872/4885CHRM3 3348/4885 |
| US-20120309775-A1 | 4-METHYLPYRIDOPYRIMIDINONE COMPOUNDS | PI4KA, PI4KB, PIK3CA | CHUK 445/4885TLR8 4872/4885CHRM3 3348/4885 |
| US-20100137279-A1 | 4-METHYLPYRIDOPYRIMIDINONE COMPOUNDS | PI4KA, PI4KB, PIK3CA | CHUK 445/4885TLR8 4872/4885CHRM3 3348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.