Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3733137 | 1.00 | TLR8 (0.41) | TLR8CTSKPIK3CAADORA3ADORA2A | |
| SCHEMBL395254 | 0.91 | PIK3CA (0.44) | TLR8CTSKPIK3CACHRM4KCNH2 | |
| SCHEMBL3338843 | 0.81 | MEN1 (0.37) | CTSKADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL1983193 | 0.77 | CHUK (0.46) | TLR8PIK3CAADORA2AADORA1IRAK4 | |
| SCHEMBL1983195 | 0.77 | CHUK (0.46) | TLR8PIK3CAADORA2AADORA1IRAK4 | |
| SCHEMBL394569 | 0.75 | CHRM4 (0.36) | CTSKPIK3CAADORA3ADORA2AADORA2B | |
| SCHEMBL394570 | 0.75 | CHRM4 (0.36) | CTSKPIK3CAADORA3ADORA2AADORA2B | |
| SCHEMBL6235685 | 0.72 | CTSK (0.43) | CTSKMAPK1 | |
| SCHEMBL7921207 | 0.71 | SYK (0.35) | CTSKPIK3CAADORA3ADORA2AADORA2B | |
| SCHEMBL13227978 | 0.71 | SYK (0.35) | CTSKPIK3CAADORA3ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101622-B2 | Pyridopyrimidinone inhibitors of PI3Kα and mTOR | EXELIXIS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-8101622-B2 | Pyridopyrimidinone inhibitors of PI3Kα and mTOR | EXELIXIS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-8101622-B2 | Pyridopyrimidinone inhibitors of PI3Kα and mTOR | EXELIXIS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20100087456-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3K-ALPHA and mTOR | EXELIXIS, INC. (US) | 2010-04-08 | — | — | US | disclosed |
| US-20100087456-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3K-ALPHA and mTOR | EXELIXIS, INC. (US) | 2010-04-08 | — | — | US | disclosed |
| US-20100087456-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3K-ALPHA and mTOR | EXELIXIS, INC. (US) | 2010-04-08 | — | — | US | disclosed |
| WO-2010039740-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα AND MTOR | EXELIXIS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087456-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3K-ALPHA and mTOR | PIK3CD, PIK3CA, MTOR | TLR8 3987/4885CTSK 4161/4885PIK3CA 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.