Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.57 |
| ▸ | GABRP | O00591 | 9/20 | 0.55 |
| ▸ | GABRD | O14764 | 9/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.55 |
| ▸ | GABRB1 | P18505 | 9/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 9/20 | 0.55 |
| ▸ | GABRA4 | P48169 | 9/20 | 0.55 |
| ▸ | GABRE | P78334 | 9/20 | 0.55 |
| ▸ | GABRA6 | Q16445 | 9/20 | 0.55 |
| ▸ | GABRG1 | Q8N1C3 | 9/20 | 0.55 |
| ▸ | GABRG3 | Q99928 | 9/20 | 0.55 |
| ▸ | GABRQ | Q9UN88 | 9/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10647099 | 0.85 | GABRP (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1983599 | 0.85 | PIM1 (0.62) | PIM1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL12938276 | 0.85 | GABRP (0.68) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL12938258 | 0.76 | PIM1 (0.59) | PIM1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10856978 | 0.74 | GABRP (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Carbazole SCHEMBL28812670 | 0.73 | ALDH1A1 (0.74) | PIM1GABRPGABRDGABRA1GABRB1 | |
| Carbazole SCHEMBL21085173 | 0.73 | ALDH1A1 (0.74) | PIM1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL14689212 | 0.73 | PIM1 (1.00) | PIM1 | |
| SCHEMBL7496083 | 0.72 | GABRP (0.51) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1984445 | 0.71 | GABRP (0.64) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070298-A1 | DI-SUBSTITUTED 9H-PYRIDO[3,4-B]INDOLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | claimed |
| WO-2011070298-A1 | DI-SUBSTITUTED 9H-PYRIDO[3,4-B]INDOLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070298-A1 | DI-SUBSTITUTED 9H-PYRIDO[3,4-B]INDOLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |