Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 5/20 | 0.55 |
| ▸ | MC1R | Q01726 | 5/20 | 0.55 |
| ▸ | MC3R | P41968 | 4/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 1/20 | 0.48 |
| ▸ | NMT2 | O60551 | 7/20 | 0.46 |
| ▸ | NMT1 | P30419 | 7/20 | 0.46 |
| ▸ | TLR2 | O60603 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.44 |
| ▸ | MC5R | P33032 | 3/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19839630 | 1.00 | MC4R (0.55) | MC4RMC1RMC3RBCHEMETAP2 | |
| SCHEMBL19839703 | 0.90 | NMT1 (0.57) | MC4RMC1RMC3RBCHEMETAP2 | |
| SCHEMBL19839702 | 0.90 | NMT1 (0.57) | MC4RMC1RMC3RBCHEMETAP2 | |
| Hydrochloric Acid SCHEMBL19839689 | 0.89 | NMT1 (0.56) | MC4RMC1RMC3RBCHEMETAP2 | |
| Hydrochloric Acid SCHEMBL19839690 | 0.89 | NMT1 (0.56) | MC4RMC1RMC3RBCHEMETAP2 | |
| SCHEMBL28291231 | 0.89 | MC4R (0.57) | MC4RMC1RMC3RBCHEMETAP2 | |
| SCHEMBL19851498 | 0.88 | MC4R (0.51) | MC4RMC1RMC3RBCHEMETAP2 | |
| SCHEMBL19851485 | 0.73 | METAP2 (0.52) | MC4RMETAP2METAP1MC5R | |
| SCHEMBL19839551 | 0.73 | TLR2 (0.68) | MC4RMC1RMC3RTLR2 | |
| SCHEMBL19839556 | 0.73 | TLR2 (0.68) | MC4RMC1RMC3RTLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3493814-A1 | LIPID-SUBSTITUTED AMINO 1,2-AND 1,3-DIOL COMPOUNDS AS MODULATORS OF TLR2 DIMERIZATION | Neuropore Therapies, Inc. (US) | 2019-06-12 | — | — | EP | claimed |
| WO-2018026866-A1 | LIPID-SUBSTITUTED AMINO 1,2-AND 1,3-DIOL COMPOUNDS AS MODULATORS OF TLR2 DIMERIZATION | NEUROPORE THERAPIES, INC. (US) | 2018-02-08 | — | — | WO | claimed |
| EP-3493814-A1 | LIPID-SUBSTITUTED AMINO 1,2-AND 1,3-DIOL COMPOUNDS AS MODULATORS OF TLR2 DIMERIZATION | Neuropore Therapies, Inc. (US) | 2019-06-12 | — | — | EP | disclosed |
| WO-2018026866-A1 | LIPID-SUBSTITUTED AMINO 1,2-AND 1,3-DIOL COMPOUNDS AS MODULATORS OF TLR2 DIMERIZATION | NEUROPORE THERAPIES, INC. (US) | 2018-02-08 | — | — | WO | disclosed |