Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TLR2 | O60603 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19839847 | 1.00 | MAPT (0.51) | MAPTNPSR1MEN1KMT2ACA1 | |
| SCHEMBL19839791 | 0.91 | CA1 (0.52) | MAPTNPSR1MEN1KMT2ACA1 | |
| SCHEMBL19839794 | 0.91 | CA1 (0.52) | MAPTNPSR1MEN1KMT2ACA1 | |
| SCHEMBL19839686 | 0.85 | MEN1 (0.55) | MAPTNPSR1MEN1KMT2ACA1 | |
| SCHEMBL19839675 | 0.85 | MEN1 (0.55) | MAPTNPSR1MEN1KMT2ACA1 | |
| SCHEMBL19839673 | 0.85 | MEN1 (0.55) | MAPTNPSR1MEN1KMT2ACA1 | |
| SCHEMBL10424905 | 0.84 | MAPT (0.54) | MAPTNPSR1MEN1KMT2ACA1 | |
| SCHEMBL15199987 | 0.83 | CTSK (0.44) | MAPTMEN1KMT2ACA1CA2 | |
| SCHEMBL8091300 | 0.83 | MAPT (0.61) | MAPTCA1CA2ABCB1MMP2 | |
| SCHEMBL8083532 | 0.83 | MAPT (0.61) | MAPTCA1CA2ABCB1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3493814-A1 | LIPID-SUBSTITUTED AMINO 1,2-AND 1,3-DIOL COMPOUNDS AS MODULATORS OF TLR2 DIMERIZATION | Neuropore Therapies, Inc. (US) | 2019-06-12 | — | — | EP | disclosed |
| WO-2018026866-A1 | LIPID-SUBSTITUTED AMINO 1,2-AND 1,3-DIOL COMPOUNDS AS MODULATORS OF TLR2 DIMERIZATION | NEUROPORE THERAPIES, INC. (US) | 2018-02-08 | — | — | WO | disclosed |