SCHEMBL1983998

SCHEMBL1983998

C[C@H](N)C(=O)Oc1ccc(Br)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ELANE P08246 2/20 0.47
MAPT P10636 2/20 0.45
LDHA P00338 1/20 0.44
LMNA P02545 2/20 0.43
RAB9A P51151 2/20 0.43
MEN1 O00255 1/20 0.43
MAPK1 P28482 1/20 0.43
KMT2A Q03164 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
RXFP1 Q9HBX9 1/20 0.43
ALDH1A1 P00352 3/20 0.41
KDM4E B2RXH2 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MGLL Q99685 1/20 0.41
ALOX5 P09917 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA9 Q16790 1/20 0.38
NCEH1 Q6PIU2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27595245 0.98 ELANE (0.46) ELANEMAPTLDHALMNARAB9A
SCHEMBL23493150 0.90 ELANE (0.55) ELANEMAPTLMNARAB9AMEN1
SCHEMBL15679080 0.90 ELANE (0.55) ELANEMAPTLMNARAB9AMEN1
Hydrochloric Acid SCHEMBL30184762 0.88 ELANE (0.53) ELANEMAPTLMNARAB9AMEN1
SCHEMBL28774734 0.85 ELANE (0.44) ELANEMAPTLDHALMNARAB9A
SCHEMBL28774735 0.85 ELANE (0.44) ELANEMAPTLDHALMNARAB9A
SCHEMBL12616891 0.84 ELANE (0.66) ELANEMAPTLDHALMNARAB9A
SCHEMBL3199570 0.82 ELANE (0.48) ELANELMNARAB9AALDH1A1SMN1; SMN2
SCHEMBL15679089 0.82 ELANE (0.48) ELANEMAPTMEN1KMT2AKDM4E
SCHEMBL5058438 0.82 LMNA (0.55) ELANEMAPTLMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 360 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119410678-A Method for optimizing antibody expression AMBRX公司 2025-02-11 CN claimed
CN-112313336-B Method for optimizing antibody expression AMBRX公司 2024-12-03 CN claimed
EP-4402259-A2 COMPOSITION OF TRANSFER RNAS AND USE IN PRODUCTION OF PROTEINS CONTAINING NON-STANDARD AMINO ACIDS ABSCI Corporation (US) 2024-07-24 EP claimed
WO-2023044431-A2 COMPOSITION OF TRANSFER RNAS AND USE IN PRODUCTION OF PROTEINS CONTAINING NON-STANDARD AMINO ACIDS Absci Corporation (US) 2023-03-23 WO claimed
EP-3788149-A1 A METHOD FOR OPTIMIZING ANTIBODY EXPRESSION Ambrx, Inc. (US) 2021-03-10 EP claimed
CN-110506049-A For combining the peptide ligand of MT1-MMP BICYCLETX LTD 2019-11-26 CN claimed
CN-110437297-A The inhibitor of farnesoid X receptor and purposes in medicine US HEALTH 2019-11-12 CN claimed
CN-105593237-B Inhibitors of farnesoid X receptor and use in medicine 美国卫生和人力服务部 2019-06-04 CN claimed
CN-104583235-B Antibodies comprising site-specific unnatural amino acid residues, methods of making and using the same 苏特罗生物制药公司 2019-03-01 CN claimed
CN-109414510-A Bicyclic peptide-the toxin-conjugate of MT1-MMP specificity 拜斯科阿迪有限公司 2019-03-01 CN claimed
CN-103215227-A Expanding the eukaryotic genetic code SCRIPPS RESEARCH INST 2013-07-24 CN claimed
CN-101223272-B Expanding the eukaryotic genetic code SCRIPPS RESEARCH INST 2013-04-03 CN claimed
WO-2012175223-A1 CATHEPSIN-BINDING COMPOUNDS BOUND TO A CARRIER AND THEIR DIAGNOSTIC USE J. STEFAN INSTITUTE (SI) 2012-12-27 WO claimed
CN-101939410-A In vivo unnatural amino acid expression in methylotrophic yeast Pichia pastoris SCRIPPS RESEARCH INST 2011-01-05 CN claimed
CN-101511856-A Suppressor TRNA transcription in vertebrate cells AMBRX INC (US) 2009-08-19 CN claimed
CN-101238143-A Incorporation of non-naturally encoded amino acids into proteins AMBRX INC (US) 2008-08-06 CN claimed
CN-101223272-A Expanding the eukaryotic genetic code SCRIPPS RESEARCH INST (US) 2008-07-16 CN claimed
EP-1490483-A2 IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS The Scripps Research Institute (US) 2004-12-29 EP claimed
WO-2002085923-A2 IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS THE SCRIPPS RESEARCH INSTITUTE (US) 2002-10-31 WO claimed
CN-1362967-A D-amino acid-containing regulator of beta-amyloid peptide aggregation PRAECIS PHARM INC (US) 2002-08-07 CN claimed