Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 5/20 | 0.48 |
| ▸ | CA2 | P00918 | 5/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.48 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15679080 | 0.92 | ELANE (0.55) | ELANEPARP10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL23493150 | 0.92 | ELANE (0.55) | ELANEPARP10CYP1A2CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL30184762 | 0.90 | ELANE (0.53) | ELANEPARP10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL28774781 | 0.85 | ELANE (0.46) | ELANECA1CA2PARP10PARP1 | |
| SCHEMBL28774783 | 0.85 | ELANE (0.46) | ELANECA1CA2PARP10PARP1 | |
| SCHEMBL15679089 | 0.84 | ELANE (0.48) | ELANECA1CA2PARP10CA12 | |
| SCHEMBL2402636 | 0.84 | ELANE (0.48) | ELANECA1CA2PARP10CA12 | |
| SCHEMBL5058438 | 0.84 | LMNA (0.55) | ELANECYP1A2CYP2C9CYP2C19LMNA | |
| SCHEMBL239299 | 0.84 | ELANE (0.48) | ELANEPARP10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL12616903 | 0.83 | ELANE (0.68) | ELANECA1CA2PARP10PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950046-B1 | 3,4-DISUBSTITUTED AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE REGULATORS | NAEJA PHARMACEUTICAL INC (CA) | 2002-04-10 | — | — | EP | claimed |
| CN-1112125-A | Acyloxyhexanoic acid derivatives | CIBA GEIGY AG (CH) | 1995-11-22 | — | — | CN | claimed |
| EP-0320204-A2 | Renin inhibiting dipeptides, their preparation and compositions containing them | GLAXO GROUP LIMITED (GB) | 1989-06-14 | — | — | EP | claimed |
| EP-0320205-A2 | Renin inhibiting dipeptides, their preparation and compositions containing them | GLAXO GROUP LIMITED (GB) | 1989-06-14 | — | — | EP | claimed |
| US-20230365646-A1 | AZIDE INSULIN ANALOGUES | MERCK SHARP & DOHME LLC (US) | 2023-11-16 | — | — | US | disclosed |
| US-20210163568-A1 | AZIDE INSULIN ANALOGUES | MERCK SHARP & DOHME CORP. (US) | 2021-06-03 | — | — | US | disclosed |
| EP-3773683-A1 | AZIDE INSULIN ANALOGUES | Merck Sharp&Dohme Corp. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3270977-B1 | OPTICAL PROBES FOR MATRIX METALLOPROTEINASES | UNIV COURT UNIV OF EDINBURGH (GB) | 2020-06-17 | — | — | EP | disclosed |
| EP-3661955-A1 | CYTOKINE CONJUGATES FOR THE TREATMENT OF AUTOIMMUNE DISEASES | Synthorx, Inc. (US) | 2020-06-10 | — | — | EP | disclosed |
| WO-2019199628-A1 | AZIDE INSULIN ANALOGUES | MERCK SHARP & DOHME CORP. (US) | 2019-10-17 | — | — | WO | disclosed |
| WO-2019028425-A1 | CYTOKINE CONJUGATES FOR THE TREATMENT OF AUTOIMMUNE DISEASES | Synthorx, Inc. (US) | 2019-02-07 | — | — | WO | disclosed |
| CN-104387372-B | Oxo azetidine derivatives, preparation method and its purposes in human medical and cosmetics | 盖尔德马研究及发展公司 | 2018-06-26 | — | — | CN | disclosed |
| EP-1679302-A1 | AROMATIC AMINO ACID LABELED WITH STABLE ISOTOPE, METHOD FOR INCORPORATING THE SAME INTO TARGET PROTEIN AND METHOD FOR ANALYZING PROTEIN STRUCTURE USING NMR | Japan Science and Technology Agency (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2006009623-A1 | DETECTION OF PROTEIN EXPRESSION IN VIVO USING FLUORESCENT PUROMYCIN CONJUGATES | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2006-01-26 | — | — | WO | disclosed |
| CN-1142492-A | Substituted N-(indole-2-carbonyl)-glycinamides and derivatives as antidiabetic agents | PFIZER (US) | 1997-02-12 | — | — | CN | disclosed |
| CN-1112125-A | Acyloxyhexanoic acid derivatives | CIBA GEIGY AG (CH) | 1995-11-22 | — | — | CN | disclosed |
| EP-0320204-A3 | RENIN INHIBITING DIPEPTIDES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1991-07-24 | — | — | EP | disclosed |
| EP-0320205-A3 | RENIN INHIBITING DIPEPTIDES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1991-07-24 | — | — | EP | disclosed |
| EP-0320204-A2 | Renin inhibiting dipeptides, their preparation and compositions containing them | GLAXO GROUP LIMITED (GB) | 1989-06-14 | — | — | EP | disclosed |
| EP-0320205-A2 | Renin inhibiting dipeptides, their preparation and compositions containing them | GLAXO GROUP LIMITED (GB) | 1989-06-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163568-A1 | AZIDE INSULIN ANALOGUES | IAPP, INSR, GPR119 | ELANE 2441/4885CA1 3176/4885CA2 3451/4885 |
| US-20230365646-A1 | AZIDE INSULIN ANALOGUES | IAPP, INSR, GPR119 | ELANE 2441/4885CA1 3176/4885CA2 3451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.