Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19842039 | 0.83 | LMNA (0.44) | MAPTTP53NPC1RAB9ALMNA | |
| SCHEMBL18084840 | 0.81 | MAPT (0.66) | MAPTTP53RAB9ALMNASMN1; SMN2 | |
| SCHEMBL20647684 | 0.80 | MAPT (0.39) | MAPTTP53LMNASMN1; SMN2ALOX12 | |
| SCHEMBL20647677 | 0.79 | MAPT (0.46) | MAPTTP53ATAD2CECR2LMNA | |
| SCHEMBL20647806 | 0.79 | MAPT (0.45) | MAPTTP53ATAD2CECR2LMNA | |
| SCHEMBL16903062 | 0.78 | MAPT (0.64) | MAPTTP53RAB9ALMNASMN1; SMN2 | |
| SCHEMBL19841959 | 0.78 | MAPT (0.39) | MAPTTP53HSD11B1ATAD2CECR2 | |
| SCHEMBL20647815 | 0.77 | MAPT (0.47) | MAPTTP53NPC1RAB9ALMNA | |
| SCHEMBL19841965 | 0.76 | HSD11B1 (0.43) | MAPTTP53HSD11B1NPC1RAB9A | |
| SCHEMBL20647771 | 0.76 | ENPP2 (0.45) | MAPTTP53RAB9ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884831-B2 | Azocane and azonane derivatives and methods of treating hepatitis B infections | NOVIRA THERAPEUTICS, INC. (US) | 2018-02-06 | — | — | US | disclosed |