Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.76 |
| ▸ | MMP9 | P14780 | 1/20 | 0.76 |
| ▸ | MMP8 | P22894 | 1/20 | 0.76 |
| ▸ | MMP13 | P45452 | 1/20 | 0.76 |
| ▸ | SULT1A1 | P50225 | 3/20 | 0.70 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.70 |
| ▸ | APP | P05067 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | SNCA | P37840 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1998019 | 0.88 | APP (0.70) | MMP2MMP9MMP8MMP13SULT1A1 | |
| SCHEMBL2192885 | 0.88 | APP (0.70) | MMP2MMP9MMP8MMP13SULT1A1 | |
| SCHEMBL2196490 | 0.88 | SULT1A1 (0.64) | MMP2MMP9MMP8MMP13SULT1A1 | |
| SCHEMBL1984153 | 0.87 | MMP2 (0.74) | MMP2MMP9MMP8MMP13APP | |
| SCHEMBL1987139 | 0.86 | MMP2 (1.00) | MMP2MMP9MMP8MMP13MAPT | |
| SCHEMBL2194415 | 0.85 | APP (0.72) | MMP2MMP9MMP8MMP13SULT1A1 | |
| SCHEMBL2193632 | 0.84 | SULT1A1 (0.65) | MMP2MMP9MMP8MMP13SULT1A1 | |
| SCHEMBL12422218 | 0.84 | SULT1A1 (0.68) | MMP2MMP9MMP8MMP13SULT1A1 | |
| SCHEMBL1983311 | 0.84 | MMP2 (0.69) | MMP2MMP9MMP8MMP13APP | |
| SCHEMBL12421981 | 0.84 | MAPT (0.74) | MMP2MMP9MMP8MMP13SULT1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2338059-A1 | LIGANDS FOR AGGREGATED TAU MOLECULES | Wista Laboratories Ltd. (SG) | 2011-06-29 | — | — | EP | disclosed |