Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 0.70 |
| ▸ | SULT1A1 | P50225 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MMP2 | P08253 | 1/20 | 0.59 |
| ▸ | MMP9 | P14780 | 1/20 | 0.59 |
| ▸ | MMP8 | P22894 | 1/20 | 0.59 |
| ▸ | MMP13 | P45452 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | MGAM | O43451 | 1/20 | 0.53 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.52 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2192885 | 0.89 | APP (0.70) | APPSULT1A1MAPTMMP2MMP9 | |
| SCHEMBL1984367 | 0.88 | MMP2 (0.76) | APPSULT1A1MAPTMMP2MMP9 | |
| SCHEMBL12422009 | 0.88 | MAPT (0.73) | APPMAPTMMP2MMP9MMP8 | |
| SCHEMBL12422020 | 0.87 | MAPT (0.62) | APPSULT1A1MAPTLMNADYRK1A | |
| SCHEMBL2194415 | 0.86 | APP (0.72) | APPSULT1A1MAPTMMP2MMP9 | |
| SCHEMBL2192963 | 0.85 | APP (0.71) | APPMAPTMMP2MMP9MMP8 | |
| SCHEMBL12509563 | 0.84 | SULT1A1 (0.59) | APPSULT1A1MAPTMMP2MMP9 | |
| SCHEMBL12421981 | 0.84 | MAPT (0.74) | APPSULT1A1MAPTMMP2MMP9 | |
| SCHEMBL9238817 | 0.84 | APP (1.00) | APPSULT1A1MAPT | |
| SCHEMBL16256408 | 0.83 | SULT1A1 (0.57) | APPSULT1A1MAPTMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180028694-A1 | THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-02-01 | — | — | US | disclosed |
| US-20180028694-A1 | THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-02-01 | — | — | US | disclosed |
| US-9808541-B2 | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition | University of Pittsburgh—Of the Commonwealth System of Higher Eduation (US) | 2017-11-07 | — | — | US | disclosed |
| US-9808541-B2 | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition | University of Pittsburgh—Of the Commonwealth System of Higher Eduation (US) | 2017-11-07 | — | — | US | disclosed |
| US-20150165073-A1 | THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2015-06-18 | — | — | US | disclosed |
| US-20150165073-A1 | THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2015-06-18 | — | — | US | disclosed |
| EP-2338059-B1 | Ligands for aggregated tau molecules | WISTA LAB LTD (SG) | 2015-04-08 | — | — | EP | disclosed |
| EP-2338059-B1 | Ligands for aggregated tau molecules | WISTA LAB LTD (SG) | 2015-04-08 | — | — | EP | disclosed |
| US-8911707-B2 | Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2014-12-16 | — | — | US | disclosed |
| US-8911707-B2 | Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2014-12-16 | — | — | US | disclosed |
| US-20080305040-A1 | In Vivo or in Vitro Method For Detecting Amyloid Deposits Having at Least One Amyloidogenic Protein | UNIVERSITY OF PITTSBURGH | 2008-12-11 | — | — | US | disclosed |
| US-20080286202-A1 | Method of Diagnosing Prodromal Forms of Diseases Associated With Amyloid Deposition | UNIVERSITY OF PITTSBURGH (US) | 2008-11-20 | — | — | US | disclosed |
| US-20080286202-A1 | Method of Diagnosing Prodromal Forms of Diseases Associated With Amyloid Deposition | UNIVERSITY OF PITTSBURGH (US) | 2008-11-20 | — | — | US | disclosed |
| US-20080219931-A1 | Amyloid Imaging as a Surrogate Marker for Efficacy of Anti-Amyloid Therapies | UNIVERSITY OF PITTSBURGH | 2008-09-11 | — | — | US | disclosed |
| US-20080219931-A1 | Amyloid Imaging as a Surrogate Marker for Efficacy of Anti-Amyloid Therapies | UNIVERSITY OF PITTSBURGH | 2008-09-11 | — | — | US | disclosed |
| US-20080021077-A1 | Bioavailability, nontoxic; 2-(3'-Iodo-4'-aminophenyl)-6-methoxybenzothiazole | UNIVERSITY OF PITTSBURGH | 2008-01-24 | — | — | US | disclosed |
| US-20080021077-A1 | Bioavailability, nontoxic; 2-(3'-Iodo-4'-aminophenyl)-6-methoxybenzothiazole | UNIVERSITY OF PITTSBURGH | 2008-01-24 | — | — | US | disclosed |
| US-7270800-B2 | Imaging amyloid deposits in living patients, with an amyloid binding agents having radiolabeled iodine; radiotherapy | UNIVERSITY OF PITTSBURGH (US) | 2007-09-18 | — | — | US | disclosed |
| US-7270800-B2 | Imaging amyloid deposits in living patients, with an amyloid binding agents having radiolabeled iodine; radiotherapy | UNIVERSITY OF PITTSBURGH (US) | 2007-09-18 | — | — | US | disclosed |
| WO-2007035405-A2 | IN-VIVO AND IN-VITRO METHOD FOR DETECTING AMYLOID DEPOSITS HAVING AT LEAST ONE AMYLOIDOGENIC PROTEIN | UNIVERSITY OF PITTSBURGH (US) | 2007-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180028694-A1 | THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION | APP, PSEN2, MAPT | APP 1/4885SULT1A1 642/4885MAPT 3/4885 |
| US-20150165073-A1 | THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION | APP, PSEN2, MAPT | APP 1/4885SULT1A1 642/4885MAPT 3/4885 |
| US-20080021077-A1 | Bioavailability, nontoxic; 2-(3'-Iodo-4'-aminophenyl)-6-methoxybenzothiazole | APOL1, APOB, APP | APP 3/4885SULT1A1 639/4885MAPT 6/4885 |
| US-20080219931-A1 | Amyloid Imaging as a Surrogate Marker for Efficacy of Anti-Amyloid Therapies | TTR, APP, SAAL1 | APP 2/4885SULT1A1 2536/4885MAPT 14/4885 |
| US-20080286202-A1 | Method of Diagnosing Prodromal Forms of Diseases Associated With Amyloid Deposition | PSEN2, PSEN1, APP | APP 3/4885SULT1A1 4158/4885MAPT 13/4885 |
| US-20080305040-A1 | In Vivo or in Vitro Method For Detecting Amyloid Deposits Having at Least One Amyloidogenic Protein | TTR, APBA1, APP | APP 3/4885SULT1A1 3850/4885MAPT 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.