Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979322 | 0.87 | MERTK (0.47) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL1984450 | 0.81 | MERTK (0.38) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL1980019 | 0.79 | CHEK2 (0.40) | ALDH1A1PDE2APDE10A | |
| SCHEMBL1979336 | 0.77 | NPC1 (0.44) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL12597604 | 0.76 | FFAR4 (0.37) | KMT2ANPC1RAB9AMERTKMEN1 | |
| SCHEMBL1663359 | 0.75 | MAPT (0.55) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL16025774 | 0.73 | MAPT (0.64) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL30686032 | 0.73 | MAPT (0.47) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL28528923 | 0.73 | MAPT (0.47) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL12597372 | 0.72 | MAOA (0.40) | TDP1HPGDKDM4EPDE2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |