Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1984450 | 0.87 | MERTK (0.38) | MERTKPIN1MAPTALDH1A1LMNA | |
| SCHEMBL1984451 | 0.87 | MAPT (0.41) | MERTKMAPTALDH1A1LMNAHPGD | |
| SCHEMBL11199415 | 0.81 | ALDH1A1 (0.54) | MERTKMAPTALDH1A1LMNAHPGD | |
| SCHEMBL12597604 | 0.81 | FFAR4 (0.37) | MERTKPIN1MAPK1KMT2ANPC1 | |
| SCHEMBL1983238 | 0.76 | HSP90AA1 (0.47) | MAPTALDH1A1HPGDGFERMAPK1 | |
| SCHEMBL1629413 | 0.75 | MAPK1 (0.58) | MERTKPIN1MAPTALDH1A1LMNA | |
| SCHEMBL30310607 | 0.75 | MAPK1 (0.58) | MERTKPIN1MAPTALDH1A1LMNA | |
| SCHEMBL1979039 | 0.74 | ALDH1A1 (0.47) | PIN1MAPTALDH1A1LMNAHPGD | |
| SCHEMBL22604633 | 0.73 | MERTK (0.56) | MERTKPIN1MAPTALDH1A1LMNA | |
| SCHEMBL541479 | 0.72 | ALDH1A1 (0.68) | MERTKMAPTALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |