Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979322 | 0.87 | MERTK (0.47) | MERTKMAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL1984451 | 0.81 | MAPT (0.41) | MERTKMAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL1980018 | 0.79 | KDM1A (0.34) | LMNASMN1; SMN2 | |
| SCHEMBL1979335 | 0.77 | PIN1 (0.37) | ALDH1A1MAPK1HPGDTDP1PIN1 | |
| SCHEMBL12597604 | 0.76 | FFAR4 (0.37) | MERTKMAPK1PIN1MEN1KMT2A | |
| SCHEMBL28059438 | 0.74 | ALDH1A1 (0.53) | MAPTALDH1A1LMNAMAPK1HPGD | |
| SCHEMBL1981547 | 0.70 | ALDH1A1 (0.42) | MAPTALDH1A1LMNAMAPK1HPGD | |
| SCHEMBL1979039 | 0.68 | ALDH1A1 (0.47) | MAPTALDH1A1LMNAMAPK1HPGD | |
| SCHEMBL11199415 | 0.67 | ALDH1A1 (0.54) | MERTKMAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL268657 | 0.67 | TDP1 (0.57) | MAPTALDH1A1LMNAMAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |