Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.72 |
| ▸ | RAB9A | P51151 | 10/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | TP53 | P04637 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.66 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.66 |
| ▸ | RELA | Q04206 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.60 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13930928 | 0.86 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2MAPK1TDP1 | |
| SCHEMBL3261409 | 0.86 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2MAPK1TDP1 | |
| SCHEMBL13930916 | 0.86 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2MAPK1TDP1 | |
| SCHEMBL13930879 | 0.84 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2MAPK1TDP1 | |
| SCHEMBL4552532 | 0.80 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MAPK1TDP1 | |
| SCHEMBL13171433 | 0.79 | RAB9A (0.72) | NPC1RAB9ASMN1; SMN2MAPK1TDP1 | |
| SCHEMBL7088210 | 0.77 | MAOA (0.50) | NPC1RAB9ASMN1; SMN2MAPK1TDP1 | |
| SCHEMBL18292342 | 0.76 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2MAPK1TDP1 | |
| SCHEMBL8016715 | 0.76 | RAB9A (0.53) | NPC1RAB9ASMN1; SMN2MAPK1TDP1 | |
| SCHEMBL3263301 | 0.75 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035793-B2 | Method for producing 1,2,4-oxadiazole derivative | ASAHI GLASS COMPANY, LIMITED (JP) | 2018-07-31 | — | — | US | disclosed |
| US-10035793-B2 | Method for producing 1,2,4-oxadiazole derivative | ASAHI GLASS COMPANY, LIMITED (JP) | 2018-07-31 | — | — | US | disclosed |
| US-20180037578-A1 | METHOD FOR PRODUCING 1,2,4-OXADIAZOLE DERIVATIVE | ASAHI GLASS COMPANY, LIMITED (JP) | 2018-02-08 | — | — | US | disclosed |
| US-20180037578-A1 | METHOD FOR PRODUCING 1,2,4-OXADIAZOLE DERIVATIVE | ASAHI GLASS COMPANY, LIMITED (JP) | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10035793-B2 | Method for producing 1,2,4-oxadiazole derivative | CBR3, CBR1, HSD3B1 | NPC1 1591/4885RAB9A 3787/4885SMN1; SMN2 4774/4885 |
| US-20180037578-A1 | METHOD FOR PRODUCING 1,2,4-OXADIAZOLE DERIVATIVE | CBR3, CBR1, HSD3B1 | NPC1 1591/4885RAB9A 3787/4885SMN1; SMN2 4774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.