Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 1.00 |
| ▸ | NPC1 | O15118 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.76 |
| ▸ | GAA | P10253 | 1/20 | 0.76 |
| ▸ | HTT | P42858 | 1/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19851081 | 0.91 | ALDH1A1 (0.83) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL206058 | 0.90 | RAB9A (0.81) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL27754680 | 0.88 | MAPT (0.79) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| Fanetizole SCHEMBL1813401 | 0.88 | GAA (0.86) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL205694 | 0.87 | RAB9A (0.76) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| Fanetizole SCHEMBL11365554 | 0.86 | GAA (0.84) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL12297576 | 0.85 | GAA (0.82) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6962738 | 0.83 | ALDH1A1 (0.70) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL207261 | 0.82 | RAB9A (0.70) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| Fanetizole SCHEMBL287000 | 0.82 | GAA (0.72) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10947207-B2 | GP130 modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-03-16 | — | — | US | disclosed |
| US-10947207-B2 | GP130 modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-03-16 | — | — | US | disclosed |
| US-20190292161-A1 | GP130 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-09-26 | — | — | US | disclosed |
| US-20190292161-A1 | GP130 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-09-26 | — | — | US | disclosed |
| WO-2018027193-A1 | GP130 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190292161-A1 | GP130 MODULATORS | GRIN2A, GRIA4, GRIA3 | RAB9A 2645/4885NPC1 1149/4885ALDH1A1 2676/4885 |
| US-10947207-B2 | GP130 modulators | GRIN2A, GRIA4, GRIA3 | RAB9A 2645/4885NPC1 1149/4885ALDH1A1 2676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.