Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.83 |
| ▸ | RAB9A | P51151 | 6/20 | 0.83 |
| ▸ | NPC1 | O15118 | 6/20 | 0.83 |
| ▸ | MAPT | P10636 | 5/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19851055 | 0.91 | RAB9A (1.00) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL205954 | 0.85 | ALDH1A1 (0.84) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL205694 | 0.85 | RAB9A (0.76) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL12297576 | 0.85 | GAA (0.82) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL19850997 | 0.84 | RAB9A (0.59) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| Fanetizole SCHEMBL1813401 | 0.82 | GAA (0.86) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL206058 | 0.82 | RAB9A (0.81) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| Fanetizole SCHEMBL11365554 | 0.81 | GAA (0.84) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL27754680 | 0.81 | MAPT (0.79) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL206769 | 0.79 | ALDH1A1 (0.90) | ALDH1A1RAB9ANPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018027193-A1 | GP130 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-02-08 | — | — | WO | disclosed |