Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18307178 | 0.81 | LMNA (0.47) | HDAC8HDAC6MEN1KMT2AKDM4E | |
| SCHEMBL27658745 | 0.81 | AOC2 (0.56) | HDAC8HDAC6MEN1KMT2ACYP1A2 | |
| SCHEMBL12688085 | 0.80 | HDAC8 (0.65) | HDAC8HDAC6MEN1KMT2AKDM4E | |
| SCHEMBL14820608 | 0.78 | HDAC6 (0.63) | HDAC8HDAC6MEN1KMT2AKDM4E | |
| SCHEMBL6184682 | 0.78 | MEN1 (0.63) | HDAC8HDAC6MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12938972 | 0.78 | KMT2A (0.63) | HDAC8HDAC6MEN1KMT2AKDM4E | |
| SCHEMBL15522678 | 0.78 | HDAC1 (0.74) | HDAC8HDAC6MEN1KMT2AKDM4E | |
| SCHEMBL27485540 | 0.78 | GAA (0.66) | HDAC8HDAC6MEN1KMT2AKDM4E | |
| Phenylacetohydroxamic Acid SCHEMBL213873 | 0.77 | HDAC8 (1.00) | HDAC8HDAC6MEN1KMT2AHDAC10 | |
| SCHEMBL211138 | 0.77 | HDAC8 (0.67) | HDAC8HDAC6MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10807953-B2 | Processes and intermediates for the preparation of Pimavanserin | PLIVA HRVATSKA D.O.O. (HR) | 2020-10-20 | — | — | US | disclosed |
| US-20190276401-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIMAVANSERIN | PLIVA HRVATSKA D.O.O. (HR) | 2019-09-12 | — | — | US | disclosed |
| US-10343993-B2 | Processes and intermediates for the preparation of Pimavanserin | PLIVA HRVATSKA D.O.O. (HR) | 2019-07-09 | — | — | US | disclosed |
| US-20180037549-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIMAVANSERIN | TAPI CROATIA INDUSTRIES LTD (HR) | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10807953-B2 | Processes and intermediates for the preparation of Pimavanserin | PIM1, PIM3, PIM2 | HDAC8 3762/4885HDAC6 3692/4885MEN1 3691/4885 |
| US-10343993-B2 | Processes and intermediates for the preparation of Pimavanserin | PIM1, PIM3, PIM2 | HDAC8 3762/4885HDAC6 3692/4885MEN1 3691/4885 |
| US-20190276401-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIMAVANSERIN | PIM1, PIM3, PIM2 | HDAC8 3762/4885HDAC6 3692/4885MEN1 3691/4885 |
| US-20180037549-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIMAVANSERIN | PIM1, PIM3, PIM2 | HDAC8 3762/4885HDAC6 3692/4885MEN1 3691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.