Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | PCNA | P12004 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4475117 | 0.81 | PLK1 (0.59) | LMNAPOLBHDAC4HTTTDP1 | |
| SCHEMBL171860 | 0.81 | HPGD (0.59) | LMNAPOLBMEN1KMT2AHPGD | |
| SCHEMBL19851593 | 0.81 | HDAC8 (0.63) | HDAC4SIGMAR1HDAC6MEN1KMT2A | |
| SCHEMBL1972574 | 0.81 | LMNA (0.68) | LMNAPOLBHDAC4HTTSIGMAR1 | |
| SCHEMBL333393 | 0.81 | LMNA (0.49) | LMNAPOLBHDAC4HTTTDP1 | |
| SCHEMBL10569182 | 0.81 | CA2 (0.56) | LMNAPOLBHDAC4HTTTDP1 | |
| SCHEMBL8135278 | 0.79 | KLKB1 (0.52) | LMNAPOLBHDAC4HTTTDP1 | |
| SCHEMBL3324450 | 0.79 | KMT2A (0.59) | LMNAHTTMEN1KMT2AKDM4E | |
| SCHEMBL1632446 | 0.79 | LMNA (0.51) | LMNAPOLBHDAC4HTTSIGMAR1 | |
| SCHEMBL14394201 | 0.79 | GLS (0.50) | LMNAPOLBHDAC4HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265607-B1 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES | RIGEL PHARMACEUTICALS INC (US) | 2016-12-14 | — | — | EP | disclosed |