Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25020926 | 0.81 | ALDH1A1 (0.73) | SMN1; SMN2ALDH1A1L3MBTL1HTTRAB9A | |
| SCHEMBL16614205 | 0.80 | ALDH1A1 (0.71) | SMN1; SMN2ALDH1A1L3MBTL1HTTEPHX2 | |
| SCHEMBL30738415 | 0.79 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1L3MBTL1HTTRAB9A | |
| SCHEMBL23976511 | 0.79 | ALDH1A1 (0.69) | SMN1; SMN2ALDH1A1L3MBTL1HTTEPHX2 | |
| SCHEMBL19699489 | 0.78 | ALDH1A1 (0.58) | SMN1; SMN2ALDH1A1L3MBTL1HTTEPHX2 | |
| SCHEMBL22775067 | 0.77 | ALDH1A1 (0.67) | SMN1; SMN2ALDH1A1L3MBTL1HTTRAB9A | |
| SCHEMBL22775284 | 0.77 | ALDH1A1 (0.67) | SMN1; SMN2ALDH1A1L3MBTL1HTTEPHX2 | |
| SCHEMBL22648389 | 0.77 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1L3MBTL1HTTRAB9A | |
| SCHEMBL22793307 | 0.77 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1L3MBTL1HTTLMNA | |
| SCHEMBL30074920 | 0.77 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1L3MBTL1HTTEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4198031-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | Merck Patent GmbH (DE) | 2023-06-21 | — | — | EP | disclosed |
| US-10947214-B2 | TLR7/8 antagonists and uses thereof | MERCK PATENT GMBH (DE) | 2021-03-16 | — | — | US | disclosed |
| US-20210002255-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2021-01-07 | — | — | US | disclosed |
| US-20200316051-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-10-08 | — | — | US | disclosed |
| US-20180037570-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200316051-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | TLR7, TLR8, TLR9 | SMN1; SMN2 43/4885ALDH1A1 2071/4885L3MBTL1 2570/4885 |
| US-20180037570-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | TLR7, TLR8, TLR9 | SMN1; SMN2 2610/4885ALDH1A1 2465/4885L3MBTL1 3637/4885 |
| US-10947214-B2 | TLR7/8 antagonists and uses thereof | TLR7, TLR8, TLR9 | SMN1; SMN2 2610/4885ALDH1A1 2465/4885L3MBTL1 3637/4885 |
| US-20210002255-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | TLR7, TLR8, TLR9 | SMN1; SMN2 1191/4885ALDH1A1 3188/4885L3MBTL1 1684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.