Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496187 | 0.78 | KMT2A (0.41) | GPR119KDM4EPKMACKR3JAK2 | |
| SCHEMBL12311356 | 0.75 | OPRD1 (0.53) | GPR119KDM4EPKMACKR3USP30 | |
| SCHEMBL5870674 | 0.74 | NAMPT (0.62) | GPR119KDM4EPKMACKR3JAK2 | |
| SCHEMBL1338962 | 0.74 | JAK2 (0.41) | GPR119KDM4EPKMJAK2JAK1 | |
| SCHEMBL2933059 | 0.74 | JAK2 (0.41) | GPR119KDM4EPKMJAK2JAK1 | |
| SCHEMBL2933063 | 0.74 | JAK2 (0.41) | GPR119KDM4EPKMJAK2JAK1 | |
| SCHEMBL4067280 | 0.74 | JAK2 (0.41) | GPR119KDM4EPKMJAK2JAK1 | |
| SCHEMBL30364768 | 0.73 | ACKR3 (0.42) | GPR119KDM4EPKMACKR3JAK2 | |
| SCHEMBL3087666 | 0.72 | KDM4E (0.70) | GPR119KDM4EPKMTGFBR1STS | |
| SCHEMBL21555085 | 0.72 | CTSL (0.46) | GPR119JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018026371-A1 | DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS | SUNOVION PHARMACEUTICALS INC. (US) | 2018-02-08 | — | — | WO | disclosed |