Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19838594 | 0.85 | SIGMAR1 (0.57) | SIGMAR1HTR1AHTR2ADRD2HTR2C | |
| SCHEMBL19852346 | 0.80 | SIGMAR1 (0.44) | SIGMAR1HTR1AMTNR1A | |
| SCHEMBL19852343 | 0.79 | SIGMAR1 (0.52) | SIGMAR1HTR2ADRD2HTR2CKCNH2 | |
| SCHEMBL19852144 | 0.77 | SIGMAR1 (0.51) | SIGMAR1HTR1AHTR2ADRD2HTR2C | |
| SCHEMBL19852304 | 0.77 | MTNR1A (0.49) | SIGMAR1HTR1AMTNR1A | |
| SCHEMBL21072108 | 0.76 | DRD2 (0.55) | SIGMAR1DRD2 | |
| SCHEMBL19852125 | 0.75 | SIGMAR1 (0.46) | SIGMAR1HTR2ADRD2HTR2CKCNH2 | |
| SCHEMBL19852145 | 0.75 | SIGMAR1 (0.46) | SIGMAR1HTR2ADRD2HTR2CKCNH2 | |
| SCHEMBL19852338 | 0.75 | SIGMAR1 (0.46) | SIGMAR1HTR2ADRD2HTR2CKCNH2 | |
| SCHEMBL19852363 | 0.75 | SIGMAR1 (0.70) | SIGMAR1HTR1AHTR2ADRD2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11186564-B2 | Dual NAV1.2/5HT2a inhibitors for treating CNS disorders | SUNOVION PHARMACEUTICALS INC. (US) | 2021-11-30 | — | — | US | disclosed |
| US-20190194163-A1 | DUAL NAV1.2/5HT2a INHIBITORS FOR TREATING CNS DISORDERS | SUNOVION PHARMACEUTICALS INC. (US) | 2019-06-27 | — | — | US | disclosed |
| WO-2018026371-A1 | DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS | SUNOVION PHARMACEUTICALS INC. (US) | 2018-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190194163-A1 | DUAL NAV1.2/5HT2a INHIBITORS FOR TREATING CNS DISORDERS | SCN2A, HTR2A, HTR2C | SIGMAR1 612/4885HTR1A 13/4885HTR2A 2/4885 |
| US-11186564-B2 | Dual NAV1.2/5HT2a inhibitors for treating CNS disorders | SCN2A, HTR2A, HTR2C | SIGMAR1 612/4885HTR1A 13/4885HTR2A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.