Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 5/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 4/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19852164 | 0.89 | SIGMAR1 (0.44) | HTR2ADRD2HTR2CHTR7SIGMAR1 | |
| SCHEMBL21072474 | 0.81 | OPRL1 (0.47) | HTR2ADRD2HTR2CHTR7SIGMAR1 | |
| SCHEMBL19852349 | 0.79 | SIGMAR1 (0.52) | HTR2ADRD2HTR2CHTR7SIGMAR1 | |
| SCHEMBL19852154 | 0.77 | OPRK1 (0.44) | HTR2AHTR2CHTR7SIGMAR1 | |
| SCHEMBL19852464 | 0.76 | GPR6 (0.41) | HTR2ADRD2HTR2CHTR7SIGMAR1 | |
| SCHEMBL19852013 | 0.76 | SIGMAR1 (0.42) | HTR2ADRD2HTR2CHTR7SIGMAR1 | |
| SCHEMBL19852159 | 0.75 | PDE10A (0.41) | HTR2ADRD2HTR2C | |
| SCHEMBL21071833 | 0.75 | PDE10A (0.41) | HTR2ADRD2HTR2C | |
| SCHEMBL19838591 | 0.74 | HTR7 (0.44) | HTR2ADRD2HTR2CHTR7SIGMAR1 | |
| Hydrochloric Acid SCHEMBL19839881 | 0.73 | HTR7 (0.43) | HTR2ADRD2HTR2CHTR7SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018026371-A1 | DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS | SUNOVION PHARMACEUTICALS INC. (US) | 2018-02-08 | — | — | WO | disclosed |