Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | BPTF | Q12830 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | HTR2C | P28335 | 5/20 | 0.40 |
| ▸ | HTR2B | P41595 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19838619 | 0.87 | OPRM1 (0.62) | OPRM1BPTFCHRNB2CHRNA4HTR2A | |
| SCHEMBL7239902 | 0.87 | OPRM1 (0.62) | OPRM1BPTFCHRNB2CHRNA4HTR2A | |
| SCHEMBL20853143 | 0.77 | CHRM2 (0.48) | OPRM1BPTFCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL24989616 | 0.75 | HRH3 (0.46) | OPRM1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL29327306 | 0.74 | HTR2C (0.51) | BPTFHTR2AHTR2CHTR2BKCNH2 | |
| SCHEMBL21852905 | 0.74 | KCNH2 (0.40) | OPRM1BPTFCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL27777689 | 0.74 | HTR2C (0.51) | BPTFHTR2AHTR2CHTR2BKCNH2 | |
| Hydrochloric Acid SCHEMBL18043605 | 0.72 | HTR2C (0.50) | BPTFHTR2AHTR2CHTR2BKCNH2 | |
| SCHEMBL25766745 | 0.71 | NPY1R (0.41) | OPRM1KCNH2 | |
| SCHEMBL25764685 | 0.70 | MBTD1 (0.45) | OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11186564-B2 | Dual NAV1.2/5HT2a inhibitors for treating CNS disorders | SUNOVION PHARMACEUTICALS INC. (US) | 2021-11-30 | — | — | US | disclosed |
| US-10370338-B2 | Benzazepine dicarboxamide compounds with tertiary amide function | HOFFMANN-LA ROCHE INC. (US) | 2019-08-06 | — | — | US | disclosed |
| US-20190194163-A1 | DUAL NAV1.2/5HT2a INHIBITORS FOR TREATING CNS DISORDERS | SUNOVION PHARMACEUTICALS INC. (US) | 2019-06-27 | — | — | US | disclosed |
| US-20190077763-A1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS WITH TERTIARY AMIDE FUNCTION | HOFFMANN-LA ROCHE INC. (US) | 2019-03-14 | — | — | US | disclosed |
| WO-2018026371-A1 | DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS | SUNOVION PHARMACEUTICALS INC. (US) | 2018-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190194163-A1 | DUAL NAV1.2/5HT2a INHIBITORS FOR TREATING CNS DISORDERS | SCN2A, HTR2A, HTR2C | OPRM1 171/4885BPTF 2707/4885CHRNB2 33/4885 |
| US-11186564-B2 | Dual NAV1.2/5HT2a inhibitors for treating CNS disorders | SCN2A, HTR2A, HTR2C | OPRM1 171/4885BPTF 2707/4885CHRNB2 33/4885 |
| US-10370338-B2 | Benzazepine dicarboxamide compounds with tertiary amide function | TLR1, TLR5, TLR4 | OPRM1 1883/4885BPTF 1460/4885CHRNB2 2909/4885 |
| US-20190077763-A1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS WITH TERTIARY AMIDE FUNCTION | TLR1, TLR5, TLR4 | OPRM1 1883/4885BPTF 1460/4885CHRNB2 2909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.