Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2381131 | 0.78 | OPRL1 (0.57) | CHRM2CYP2D6TSHRKMT2AMEN1 | |
| SCHEMBL19853699 | 0.75 | GRIN2B (0.54) | KMT2AMEN1OPRM1OPRL1GRIN2B | |
| SCHEMBL10726346 | 0.74 | IDO1 (0.46) | KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL19853708 | 0.72 | RORC (0.39) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL8647480 | 0.70 | DPP7 (0.47) | KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL2255128 | 0.70 | DPP7 (0.52) | KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL19853709 | 0.70 | RORC (0.38) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL7695234 | 0.70 | SIGMAR1 (0.53) | CYP2D6TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL518257 | 0.69 | DPP7 (0.50) | CYP2D6TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL24178807 | 0.69 | SIGMAR1 (0.59) | CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018026763-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2018-02-08 | — | — | WO | disclosed |