Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19853708 | 0.84 | RORC (0.39) | RORCOPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL19853701 | 0.75 | GRIN2B (0.50) | CRBNKMT2AALDH1A1KDM4ETDP1 | |
| SCHEMBL2381131 | 0.74 | OPRL1 (0.57) | OPRM1OPRL1OPRD1OPRK1CHRM2 | |
| SCHEMBL19853703 | 0.72 | DDB1 (0.49) | OPRM1PARP1CHRM2CRBNALDH1A1 | |
| SCHEMBL19853711 | 0.70 | LMNA (0.36) | OPRM1OPRL1OPRD1OPRK1LMNA | |
| SCHEMBL19853712 | 0.69 | DDB1 (0.43) | OPRM1OPRL1LMNATSHRCRBN | |
| SCHEMBL24178962 | 0.69 | BCHE (0.46) | MAOBCHRM2DRD1 | |
| SCHEMBL8632726 | 0.67 | KHK (0.44) | RORCMAPTKDM4E | |
| SCHEMBL19853699 | 0.66 | GRIN2B (0.54) | OPRM1OPRL1KMT2A | |
| SCHEMBL24178875 | 0.65 | SIGMAR1 (0.46) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018026763-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2018-02-08 | — | — | WO | disclosed |