SCHEMBL198552

SCHEMBL198552

COC(=O)c1ccc(C(C)Br)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.55
CA2 P00918 3/20 0.55
CA12 O43570 2/20 0.55
CA9 Q16790 2/20 0.55
CA14 Q9ULX7 2/20 0.55
TDP1 Q9NUW8 1/20 0.55
CA7 P43166 1/20 0.55
TSHR P16473 1/20 0.52
MAPT P10636 5/20 0.50
ALDH1A1 P00352 1/20 0.50
CYP4A11 Q02928 2/20 0.49
LOXL2 Q9Y4K0 1/20 0.48
RAB9A P51151 3/20 0.48
NPC1 O15118 1/20 0.48
GAA P10253 1/20 0.47
KDM4E B2RXH2 1/20 0.47
CYP4F2 P78329 1/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
CASP3 P42574 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10610953 0.86 CA1 (0.57) CA1CA2CA12CA9CA14
SCHEMBL1028048 0.86 CA1 (0.57) CA1CA2CA12CA9CA14
SCHEMBL21831286 0.86 CA1 (0.57) CA1CA2CA12CA9CA14
SCHEMBL31455691 0.85 CA1 (0.52) CA1CA2CA12CA9CA14
SCHEMBL84424 0.83 CA1 (0.59) CA1CA2CA12CA9CA14
SCHEMBL24073028 0.83 ALDH1A1 (0.55) CA1CA2CA12CA9CA14
SCHEMBL18309215 0.82 CA1 (0.53) CA1CA2CA12CA9CA14
SCHEMBL14488009 0.82 CA1 (0.53) CA1CA2CA12CA9CA14
SCHEMBL29013792 0.82 CA1 (0.53) CA1CA2CA12CA9CA14
SCHEMBL28075695 0.82 CA1 (0.40) CA1CA2CA12CA9CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 420 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118619922-A Hydroxamic acid compound, and preparation method and application thereof 郑州大学 2024-09-10 CN claimed
CN-104530078-A Thieno [3, 2-d] pyrimidine derivative and preparation method and application thereof UNIV SHANDONG 2015-04-22 CN claimed
US-12624044-B2 SMARCA degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2026-05-12 US disclosed
US-20260041671-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS INC (US) 2026-02-12 US disclosed
US-12539292-B2 BRM targeting compounds and associated methods of use ARVINAS OPERATIONS, INC. (US) 2026-02-03 US disclosed
US-12479797-B2 Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors Jubilant Epicore LLC (US) 2025-11-25 US disclosed
EP-3455204-B1 CYCLOPROPYL-AMIDE COMPOUNDS AS DUAL LSD1/HDAC INHIBITORS Jubilant Epicore LLC (US) 2025-10-29 EP disclosed
EP-3416633-B1 TETRAHYDROQUINOLINE SUBSTITUTED HYDROXAMIC ACIDS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS UNIV ILLINOIS (US) 2025-07-23 EP disclosed
EP-4537905-A2 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE Arvinas Operations, Inc. (US) 2025-04-16 EP disclosed
WO-2025059562-A1 SUBSTITUTED AMINOPYRIDINE COMPOUNDS AND METHODS OF TREATING DISEASE USING SAME ATAVISTIK BIO, INC. (US) 2025-03-20 WO disclosed
EP-3774789-B1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS INC (US) 2025-03-05 EP disclosed
US-5234942-A Treating allergic pulmonary disorders, asthma ICI AMERICAS INC. (US) 1993-08-10 US disclosed
WO-1993009185-A1 LONG WAVELENGTH CHEMICALLY REACTIVE DIPYRROMETHENEBORON DIFLUORIDE DYES AND CONJUGATES MOLECULAR PROBES, INC. (US) 1993-05-13 WO disclosed
CN-1055925-A Pyridine derivate and preparation method thereof ICI PLC (GB) 1991-11-06 CN disclosed
CN-1050187-A New quinoline compound and preparation method thereof ICI PLC (GB) 1991-03-27 CN disclosed
US-4997844-A Compounds for the treatment of allergic or inflammatory diseases or shock conditions ICI AMERICAS INC. (US) 1991-03-05 US disclosed
EP-0179619-B1 HETEROCYCLIC AMIDES ICI AMERICAS INC. (US) 1990-09-05 EP disclosed
CN-1030755-A INSECTICIDAL PYRAZOLINES DU PONT (US) 1989-02-01 CN disclosed
US-4616086-A ANTICOAGULANTS BOEHRINGER MANNHEIM GMBH (DE) 1986-10-07 US disclosed
EP-0179619-A1 Heterocyclic amides ICI AMERICAS INC. (US) 1986-04-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12539292-B2 BRM targeting compounds and associated methods of use ADRM1, SUMO2, BAZ1A CA1 4427/4885CA2 4413/4885CA12 4283/4885
US-12479797-B2 Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors HDAC1, HDAC11, HDAC2 CA1 1041/4885CA2 1873/4885CA12 3079/4885
US-12624044-B2 SMARCA degraders and uses thereof SMARCA1, SMARCC1, SMARCA2 CA1 2045/4885CA2 2413/4885CA12 3603/4885
US-20260041671-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ADRM1, VHL, BAZ1A CA1 4190/4885CA2 4078/4885CA12 4415/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.