Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 9/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.45 |
| ▸ | STAT5A | P42229 | 6/20 | 0.44 |
| ▸ | STAT5B | P51692 | 5/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | CASP4 | P49662 | 1/20 | 0.36 |
| ▸ | CASP5 | P51878 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CASP9 | P55211 | 1/20 | 0.36 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.36 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061326 | 0.84 | TRPV4 (0.55) | STAT6TRPV4STAT5ASTAT5BCCR1 | |
| SCHEMBL4350448 | 0.83 | STAT6 (0.40) | STAT6POLBALOX15 | |
| SCHEMBL4060306 | 0.83 | TRPV4 (0.55) | STAT6TRPV4STAT5ASTAT5BCCR1 | |
| SCHEMBL4053522 | 0.82 | TRPV4 (0.51) | STAT6TRPV4STAT5ASTAT5BCCR1 | |
| SCHEMBL4340949 | 0.81 | STAT6 (0.39) | STAT6CCR1ALOX15 | |
| SCHEMBL4053125 | 0.81 | TRPV4 (0.65) | STAT6TRPV4STAT5ASTAT5BCCR1 | |
| SCHEMBL4050277 | 0.80 | TRPV4 (0.56) | STAT6TRPV4STAT5ASTAT5BCCR1 | |
| SCHEMBL4050161 | 0.80 | TRPV4 (0.56) | STAT6TRPV4STAT5ASTAT5BCCR1 | |
| SCHEMBL4049701 | 0.80 | TRPV4 (0.65) | STAT6TRPV4STAT5ASTAT5BCCR1 | |
| SCHEMBL4338819 | 0.78 | STAT6 (0.40) | STAT6POLBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |