Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.44 |
| ▸ | FEN1 | P39748 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16824800 | 0.84 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DALOX5AP | |
| SCHEMBL16824818 | 0.81 | HSD11B1 (0.40) | PDE4APDE4BPDE4CPDE4DALOX5AP | |
| SCHEMBL16821841 | 0.75 | FEN1 (0.42) | ALOX5APFEN1GRM2 | |
| SCHEMBL16824820 | 0.75 | HDAC1 (0.41) | PDE4APDE4BPDE4CPDE4DALOX5AP | |
| SCHEMBL19857042 | 0.73 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4553905 | 0.72 | AKR1C3 (0.45) | ALOX5APFEN1AKR1C3AKR1C2PTGS2 | |
| SCHEMBL19857043 | 0.71 | CTSA (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL19857039 | 0.71 | SCN5A (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16821729 | 0.70 | HDAC1 (0.37) | ALOX5APFEN1GRM2IDO1 | |
| SCHEMBL5121382 | 0.70 | APP (0.57) | ALOX5APFEN1AKR1C3AKR1C2GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092234-B1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2018-02-14 | — | — | EP | disclosed |