Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16824800 | 0.87 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL19857043 | 0.86 | CTSA (0.51) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL16824807 | 0.85 | FFAR4 (0.47) | SCN5APPARDCYP1A2FFAR4MAOB | |
| SCHEMBL19857039 | 0.82 | SCN5A (0.46) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL19857041 | 0.80 | PPARD (0.45) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL16821860 | 0.78 | SCN5A (0.39) | SCN5APPARDCYP1A2GRM5FFAR4 | |
| SCHEMBL19857045 | 0.75 | PPARD (0.46) | SCN5APPARDFFAR4SYK | |
| SCHEMBL28177887 | 0.74 | SCN5A (0.51) | SCN5ACYP1A2FFAR4 | |
| SCHEMBL15730155 | 0.74 | DHODH (0.51) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL3733529 | 0.74 | ADORA1 (0.46) | DYRK1ASCN5ADHODHMMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092234-B1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2018-02-14 | — | — | EP | disclosed |