Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 16/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19859496 | 0.79 | EPHX2 (0.36) | EPHX2PLA2G2ATHRATHRBPTGER3 | |
| SCHEMBL19859497 | 0.79 | EPHX2 (0.36) | EPHX2PLA2G2ATHRATHRBPTGER3 | |
| SCHEMBL19859510 | 0.77 | PLA2G2A (0.36) | EPHX2PLA2G2ATHRATHRBPTGER3 | |
| SCHEMBL21046976 | 0.77 | PLA2G2A (0.36) | EPHX2PLA2G2ATHRATHRBPTGER3 | |
| SCHEMBL19859555 | 0.73 | EPHX2 (0.38) | EPHX2PLA2G2A | |
| SCHEMBL12304250 | 0.73 | TSHR (0.48) | EPHX2PLA2G2ATHRATHRBPTGER3 | |
| SCHEMBL19867684 | 0.71 | CTH (0.40) | EPHX2PLA2G2ATHRATHRBPTGER3 | |
| SCHEMBL22679904 | 0.70 | GRIA2 (0.49) | CYP2D6CYP2C19 | |
| SCHEMBL19859837 | 0.69 | NAMPT (0.44) | CYP2D6CYP2C19 | |
| SCHEMBL18792739 | 0.67 | PTGER3 (0.38) | EPHX2PLA2G2ATHRATHRBPTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3497098-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | Zafgen, Inc. (US) | 2019-06-19 | — | — | EP | claimed |
| WO-2018031877-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN, INC. (US) | 2018-02-15 | — | — | WO | claimed |