Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3684536 | 0.78 | TBXAS1 (0.43) | TBXAS1TAAR1FPR2GAASMN1; SMN2 | |
| SCHEMBL18689330 | 0.75 | FPR2 (0.55) | NAMPTFPR2SMN1; SMN2KDM4E | |
| SCHEMBL6269200 | 0.75 | TAAR1 (0.44) | TBXAS1TAAR1FDPSHTR1A | |
| SCHEMBL467243 | 0.75 | TAAR1 (0.44) | TBXAS1TAAR1FDPSHTR1A | |
| SCHEMBL6451096 | 0.75 | FPR2 (0.55) | TBXAS1TAAR1FPR2GAASMN1; SMN2 | |
| SCHEMBL26965318 | 0.74 | MMP1 (0.41) | TBXAS1TAAR1FPR2GAASMN1; SMN2 | |
| SCHEMBL27122522 | 0.74 | MMP1 (0.41) | TBXAS1TAAR1FPR2GAASMN1; SMN2 | |
| SCHEMBL4129705 | 0.73 | TXN (0.47) | TBXAS1TAAR1SMN1; SMN2FDPSHTR1A | |
| SCHEMBL7426540 | 0.72 | TERT (0.54) | NAMPTTBXAS1TAAR1FPR2GAA | |
| SCHEMBL7511041 | 0.72 | TBXAS1 (0.46) | TBXAS1TAAR1FPR2GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3497098-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | Zafgen, Inc. (US) | 2019-06-19 | — | — | EP | disclosed |
| WO-2018031877-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN, INC. (US) | 2018-02-15 | — | — | WO | disclosed |