Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.58 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.56 |
| ▸ | PRMT3 | O60678 | 2/20 | 0.54 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.52 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.52 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2163047 | 0.86 | NOTUM (0.65) | NOTUMROCK2ROCK1IMPDH2PRMT3 | |
| SCHEMBL24735962 | 0.86 | IMPDH2 (0.69) | NOTUMROCK2ALDH1A1ROCK1IMPDH2 | |
| SCHEMBL14124407 | 0.84 | ROCK2 (0.66) | NOTUMROCK2MEN1KMT2AROCK1 | |
| SCHEMBL24736063 | 0.84 | IMPDH2 (0.54) | NOTUMROCK2ROCK1IMPDH2PRMT3 | |
| SCHEMBL3586006 | 0.82 | NOTUM (0.69) | NOTUMROCK2MEN1KMT2AROCK1 | |
| SCHEMBL19860065 | 0.79 | ROCK1 (0.61) | NOTUMROCK2ALDH1A1ROCK1IMPDH2 | |
| SCHEMBL16345185 | 0.79 | ROCK2 (1.00) | NOTUMROCK2MEN1ALDH1A1KMT2A | |
| SCHEMBL30544179 | 0.79 | MEN1 (0.58) | NOTUMROCK2MEN1ALDH1A1KMT2A | |
| SCHEMBL29099854 | 0.79 | MEN1 (0.58) | NOTUMROCK2MEN1ALDH1A1KMT2A | |
| SCHEMBL2162755 | 0.78 | NOTUM (0.62) | NOTUMROCK2ROCK1IMPDH2PRMT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |