Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | UTS2R | Q9UKP6 | 6/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19861658 | 0.79 | TRPV1 (0.38) | TRPV1ALDH1A1TSHR | |
| SCHEMBL21496759 | 0.79 | TRPV1 (0.39) | TRPV1ALDH1A1TSHRKDM4EMAPT | |
| SCHEMBL13780653 | 0.79 | ACACB (0.37) | TRPV1ALDH1A1TSHR | |
| SCHEMBL4401773 | 0.77 | TRPV1 (0.44) | TRPV1ALDH1A1TSHRKDM4EMAPT | |
| SCHEMBL19861703 | 0.75 | TRPV1 (0.35) | TRPV1ALDH1A1KDM4ESMN1; SMN2UTS2R | |
| SCHEMBL2736113 | 0.72 | ALDH1A1 (0.38) | TRPV1ALDH1A1KDM4EMAPTTHRB | |
| SCHEMBL12506705 | 0.72 | PAOX (0.38) | TRPV1ALDH1A1TSHRUTS2RUSP2 | |
| SCHEMBL8145207 | 0.72 | TRPV1 (0.42) | TRPV1ALDH1A1TSHRKDM4EMAPT | |
| SCHEMBL20404606 | 0.72 | TRPV1 (0.42) | TRPV1ALDH1A1TSHRKDM4EMAPT | |
| SCHEMBL8134506 | 0.72 | TRPV1 (0.42) | TRPV1ALDH1A1TSHRKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9891239-B2 | Modulators of pharmacokinetic properties of therapeutics | GILEAD SCIENCES, INC. (US) | 2018-02-13 | — | — | US | disclosed |