Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2600740 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1MAPK14HSD17B10KMT2A | |
| SCHEMBL21237806 | 0.79 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10KMT2ASMN1; SMN2 | |
| SCHEMBL20053799 | 0.78 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10KMT2ASMN1; SMN2 | |
| SCHEMBL8720568 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1MAPK14HSD17B10KMT2A | |
| SCHEMBL8720509 | 0.77 | LMNA (0.51) | KDM4EALDH1A1MAPK14HSD17B10KMT2A | |
| SCHEMBL12797606 | 0.74 | KDM4E (0.49) | KDM4EALDH1A1MAPK14HSD17B10KMT2A | |
| SCHEMBL20858133 | 0.74 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10KMT2ASMN1; SMN2 | |
| SCHEMBL16402570 | 0.72 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10KMT2ASMN1; SMN2 | |
| SCHEMBL24655005 | 0.72 | MAPK14 (0.40) | KDM4EALDH1A1MAPK14HSD17B10SMN1; SMN2 | |
| SCHEMBL19297200 | 0.72 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890166-B2 | Imidazopyrrolidine derivatives and their use in the treatment of disease | NOVARTIS AG (CH) | 2018-02-13 | — | — | US | disclosed |