Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 4/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19297200 | 0.87 | KDM4E (0.48) | KDM4EALDH1A1LMNATDP1POLB | |
| SCHEMBL21237806 | 0.84 | KDM4E (0.50) | KDM4EALDH1A1LMNATDP1POLB | |
| SCHEMBL19297194 | 0.84 | KDM4E (0.44) | KDM4EALDH1A1LMNATDP1POLB | |
| SCHEMBL22958087 | 0.83 | KDM4E (0.43) | KDM4EALDH1A1LMNATDP1POLB | |
| SCHEMBL2600740 | 0.82 | KDM4E (0.50) | KDM4EALDH1A1LMNAKMT2AHSD17B10 | |
| SCHEMBL20858133 | 0.79 | KDM4E (0.45) | KDM4EALDH1A1LMNATDP1POLB | |
| SCHEMBL8720509 | 0.79 | LMNA (0.51) | KDM4EALDH1A1LMNATDP1POLB | |
| SCHEMBL8720568 | 0.79 | KDM4E (0.47) | KDM4EALDH1A1LMNATDP1POLB | |
| SCHEMBL26831413 | 0.79 | KDM4E (0.47) | KDM4EALDH1A1LMNATDP1POLB | |
| SCHEMBL19861782 | 0.78 | KDM4E (0.50) | KDM4EALDH1A1LMNATDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11649240-B2 | Substituted 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-05-16 | — | — | US | disclosed |
| US-20230000993-A1 | SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME | BLINKBIO INC (US) | 2023-01-05 | — | — | US | disclosed |
| US-20210363155-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-11-25 | — | — | US | disclosed |
| US-20210228563-A1 | METHODS OF TREATING RBP4 RELATED DISEASES WITH TRIAZOLOPYRIDINES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-07-29 | — | — | US | disclosed |
| US-20210214360-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-07-15 | — | — | US | disclosed |
| US-11007186-B2 | Methods of treating RBP4 related diseases with triazolopyridines | BELITE BIO, INC (KY) | 2021-05-18 | — | — | US | disclosed |
| US-10570148-B2 | N-alkyl-2-phenoxyethanamines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-02-25 | — | — | US | disclosed |
| US-20190240212-A1 | METHODS OF TREATING RBP4 RELATED DISEASES WITH TRIAZOLOPYRIDINES | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2019-08-08 | — | — | US | disclosed |
| US-10245259-B2 | Methods of treating RBP4 related diseases with triazolopyridines | BELITE BIO, INC (KY) | 2019-04-02 | — | — | US | disclosed |
| US-20180222919-A1 | N-ALKYL-2-PHENOXYETHANAMINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-08-09 | — | — | US | disclosed |
| US-9944644-B2 | Octahydropyrrolopyrroles their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10570148-B2 | N-alkyl-2-phenoxyethanamines, their preparation and use | HRH3, CBR3, KCNH3 | KDM4E 723/4885ALDH1A1 2874/4885LMNA 1859/4885 |
| US-20210363155-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | HTR3C, HRH4, CYP4F3 | KDM4E 1279/4885ALDH1A1 2713/4885LMNA 4578/4885 |
| US-10245259-B2 | Methods of treating RBP4 related diseases with triazolopyridines | RBP4, RBP1, RBBP4 | KDM4E 636/4885ALDH1A1 1947/4885LMNA 1247/4885 |
| US-20210214360-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | HRH4, HRH3, HRH2 | KDM4E 1520/4885ALDH1A1 3360/4885LMNA 3923/4885 |
| US-20210228563-A1 | METHODS OF TREATING RBP4 RELATED DISEASES WITH TRIAZOLOPYRIDINES | RBP4, RBP1, RBBP4 | KDM4E 636/4885ALDH1A1 1947/4885LMNA 1247/4885 |
| US-20230000993-A1 | SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME | CD44, MSN, AS3MT | KDM4E 3060/4885ALDH1A1 2151/4885LMNA 3473/4885 |
| US-20180222919-A1 | N-ALKYL-2-PHENOXYETHANAMINES, THEIR PREPARATION AND USE | HRH3, CBR3, KCNH3 | KDM4E 723/4885ALDH1A1 2874/4885LMNA 1859/4885 |
| US-11007186-B2 | Methods of treating RBP4 related diseases with triazolopyridines | RBP4, RBP1, RBBP4 | KDM4E 636/4885ALDH1A1 1947/4885LMNA 1247/4885 |
| US-20190240212-A1 | METHODS OF TREATING RBP4 RELATED DISEASES WITH TRIAZOLOPYRIDINES | RBP4, RBP1, RBBP4 | KDM4E 636/4885ALDH1A1 1947/4885LMNA 1247/4885 |
| US-11649240-B2 | Substituted 4-phenylpiperidines, their preparation and use | HRH4, HRH3, HRH2 | KDM4E 1520/4885ALDH1A1 3360/4885LMNA 3923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.