Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | PDE9A | O76083 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.34 |
| ▸ | GRM5 | P41594 | 5/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19865016 | 0.81 | GRM5 (0.40) | PDE9ALRRK2GRM5 | |
| SCHEMBL3410707 | 0.77 | CDK4 (0.40) | CDK4PDGFRBPDGFRAFFAR4CDK1 | |
| SCHEMBL19899744 | 0.76 | FFAR4 (0.41) | CDK4PDGFRBPDGFRAFFAR4LRRK2 | |
| SCHEMBL11788449 | 0.75 | GRM5 (0.42) | CDK4PDGFRBPDGFRAFFAR4CDK1 | |
| SCHEMBL16116472 | 0.74 | ACACB (0.42) | CDK4CDK1CDK2CDK7CDK9 | |
| SCHEMBL19510918 | 0.73 | FFAR4 (0.39) | CDK4PDGFRBPDGFRAFFAR4LRRK2 | |
| SCHEMBL12351912 | 0.73 | NOS3 (0.39) | NOS3NOS1NOS2 | |
| SCHEMBL31426424 | 0.73 | PDE2A (0.39) | CDK4PDGFRBPDGFRAFFAR4LRRK2 | |
| SCHEMBL26618046 | 0.73 | PDE2A (0.39) | CDK4PDGFRBPDGFRAFFAR4LRRK2 | |
| SCHEMBL20355536 | 0.73 | CDK4 (0.43) | CDK4PDGFRBPDGFRACDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044338-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044338-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | CDK4 1330/4885PDE9A 2060/4885PDGFRB 2694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.