Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17222668 | 0.81 | POLB (0.40) | POLBHTR2CKDM4ELMNAPKM | |
| SCHEMBL24012951 | 0.78 | POLB (0.46) | POLBKDM4ELMNAPKMKAT2B | |
| SCHEMBL17230733 | 0.74 | POLB (0.35) | POLBHTR2CKDM4ELMNAPKM | |
| SCHEMBL16015415 | 0.70 | PDE7A (0.37) | POLBKDM4ELMNAPKMKAT2B | |
| SCHEMBL18931709 | 0.70 | AGTR1 (0.37) | KDM4ELMNAHTT | |
| SCHEMBL19862662 | 0.66 | KDM1A (0.53) | CYP1A2TSHRMEN1CYP2D6NFKB1 | |
| SCHEMBL27428607 | 0.65 | CDK4 (0.37) | POLBKDM4ELMNAGSK3BALDH1A1 | |
| SCHEMBL25793112 | 0.64 | POLB (0.32) | POLBTSHRSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL18931727 | 0.64 | CA1 (0.34) | KDM4ELMNAPKMCYP3A4TSHR | |
| SCHEMBL13677280 | 0.63 | ACSS2 (0.53) | LMNACYP1A2CYP3A4SMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018031658-A1 | TREATMENT OF RELAPSED AND/OR REFRACTORY SOLID TUMORS AND NON-HODGKIN'S LYMPHOMAS | CELGENE CORPORATION (US) | 2018-02-15 | — | — | WO | disclosed |