Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 9/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 4/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL198387 | 0.88 | PDE5A (0.38) | CHEK2NR1H4CYP3A4CYP2D6DHODH | |
| SCHEMBL198630 | 0.87 | CHEK2 (0.43) | CHEK2NR1H4CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL198479 | 0.83 | DGAT1 (0.39) | CYP3A4CYP2D6DHODHDGAT1SOAT1 | |
| SCHEMBL200870 | 0.80 | PPARA (0.38) | CHEK2NR1H4CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL198729 | 0.80 | PPARA (0.37) | CYP3A4DHODHDGAT1SOAT1KCNH2 | |
| SCHEMBL198390 | 0.76 | KCNH2 (0.38) | CHEK2NR1H4CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL197864 | 0.72 | NR1H4 (0.39) | NR1H4DHODHDGAT1SOAT1KCNH2 | |
| SCHEMBL198482 | 0.71 | DGAT1 (0.39) | NR1H4CYP3A4CYP2D6DGAT1SOAT1 | |
| SCHEMBL197218 | 0.71 | NR1H4 (0.65) | NR1H4CYP3A4CYP2D6CYP2C9KCNH2 | |
| SCHEMBL200873 | 0.69 | CYP3A4 (0.38) | NR1H4CYP3A4CYP2D6CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088930-B2 | Benzimidazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20100063101-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063101-A1 | NEW BENZIMIDAZOLE DERIVATIVES | CYP3A7, ECI1, CYP2B6 | CHEK2 3015/4885TBK1 375/4885NR1H4 292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.