Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1986919 | 0.95 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNA3CHRNA7MEN1 | |
| SCHEMBL1985022 | 0.82 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNA3CHRNA7SIGMAR1 | |
| SCHEMBL1987185 | 0.81 | SIGMAR1 (0.49) | CHRNB2CHRNA3SIGMAR1MCHR1HTR6 | |
| SCHEMBL1986267 | 0.81 | SIGMAR1 (0.53) | CHRNB2CHRNA4CHRNA3CHRNA7SIGMAR1 | |
| SCHEMBL1991565 | 0.73 | MCHR1 (0.40) | SIGMAR1MCHR1 | |
| Hydrochloric Acid SCHEMBL1987318 | 0.71 | SIGMAR1 (0.59) | ALDH1A1HSD17B10SIGMAR1MCHR1HTR6 | |
| SCHEMBL1984652 | 0.69 | CHRNB2 (0.38) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNB4 | |
| SCHEMBL7757337 | 0.68 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA3CHRNA7MEN1 | |
| SCHEMBL1985618 | 0.67 | SIGMAR1 (0.46) | CHRNA7SIGMAR1MCHR1HTR6 | |
| SCHEMBL1985617 | 0.67 | SIGMAR1 (0.46) | CHRNA7SIGMAR1MCHR1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778959-B2 | AZA-bridged ring-fused indoles and indolines | ABBVIE INC. (US) | 2014-07-15 | — | — | US | claimed |
| US-20110152306-A1 | AZA-BRIDGED RING-FUSED INDOLES AND INDOLINES | ABBOTT LABORATORIES (US) | 2011-06-23 | — | — | US | claimed |
| US-8778959-B2 | AZA-bridged ring-fused indoles and indolines | ABBVIE INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-20110152306-A1 | AZA-BRIDGED RING-FUSED INDOLES AND INDOLINES | ABBOTT LABORATORIES (US) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152306-A1 | AZA-BRIDGED RING-FUSED INDOLES AND INDOLINES | INMT, IDO1, IDO2 | CHRNB2 549/4885CHRNA4 353/4885CHRNA3 262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.