Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.48 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19863781 | 0.75 | TBXA2R (0.57) | TBXA2RDCTPP1TP53CCR2ALDH1A1 | |
| SCHEMBL15685233 | 0.74 | BACE1 (0.44) | TP53TDP1KMT2A | |
| SCHEMBL18890528 | 0.72 | TP53 (0.55) | TBXA2RDCTPP1TP53CCR2ALDH1A1 | |
| SCHEMBL23535783 | 0.70 | DCTPP1 (0.46) | TBXA2RDCTPP1TP53CCR2ALDH1A1 | |
| SCHEMBL31019833 | 0.70 | CCR2 (0.58) | TBXA2RDCTPP1TP53CCR2ALDH1A1 | |
| SCHEMBL22955887 | 0.70 | TP53 (0.58) | TBXA2RDCTPP1TP53CCR2ALDH1A1 | |
| SCHEMBL5246941 | 0.70 | DCTPP1 (0.66) | TBXA2RALOX5APDCTPP1TP53CCR2 | |
| SCHEMBL9683103 | 0.70 | TBXA2R (0.79) | TBXA2RALOX5APCCR2 | |
| SCHEMBL6085466 | 0.69 | CCR2 (0.67) | TBXA2RDCTPP1TP53CCR2ALDH1A1 | |
| SCHEMBL9681521 | 0.68 | TBXA2R (1.00) | TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10577349-B2 | Quinolinones as inhibitors of translation initiation complex | Sanford Burnham Prebys Medical Discovery Institute (US) | 2020-03-03 | — | — | US | disclosed |
| US-20180044324-A1 | Quinolinones as Inhibitors of Translation Initiation Complex | Sanford Burnham Prebys Medical Discovery Institute | 2018-02-15 | — | — | US | disclosed |
| US-20180044324-A1 | Quinolinones as Inhibitors of Translation Initiation Complex | Sanford Burnham Prebys Medical Discovery Institute | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044324-A1 | Quinolinones as Inhibitors of Translation Initiation Complex | EIF4E, EIF4A1, EIF4A2 | TBXA2R 3849/4885ALOX5AP 4363/4885DCTPP1 1636/4885 |
| US-10577349-B2 | Quinolinones as inhibitors of translation initiation complex | EIF4E, EIF4A1, EIF4A2 | TBXA2R 3849/4885ALOX5AP 4363/4885DCTPP1 1636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.