Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 2/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5405855 | 0.73 | ALDH1A1 (0.46) | NQO2MTNR1AMTNR1BRAB9AALDH1A1 | |
| SCHEMBL5420166 | 0.67 | RHEB (0.44) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL2921543 | 0.66 | IDO1 (0.47) | PTGS2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL31687084 | 0.65 | TUBB1 (0.50) | — | |
| SCHEMBL25672751 | 0.64 | NQO2 (0.36) | NQO2MTNR1AMTNR1BADRB2MEN1 | |
| SCHEMBL7293866 | 0.64 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL24723387 | 0.64 | HTR2C (0.48) | NQO2MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL28235281 | 0.63 | HTR2A (0.32) | HTR2AGPR84 | |
| SCHEMBL1014275 | 0.63 | ALDH1A1 (0.50) | MEN1RAB9AKMT2ALMNAALDH1A1 | |
| SCHEMBL1710455 | 0.63 | ALDH1A1 (0.50) | MEN1RAB9AKMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11576979-B2 | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof | GENENTECH, INC. (US) | 2023-02-14 | — | — | US | disclosed |
| WO-2018031662-A1 | PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF | GENENTECH, INC. (US) | 2018-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11576979-B2 | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof | NQO1, GSTP1, CYBB | NQO2 47/4885MTNR1A 624/4885MTNR1B 427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.