Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | S100B | P04271 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5418838 | 0.74 | L3MBTL1 (0.54) | ALDH1A1MAPTL3MBTL1GAAKDM4E | |
| SCHEMBL2902810 | 0.72 | RHEB (0.40) | RHEBALDH1A1MAPTL3MBTL1KDM4E | |
| SCHEMBL23862827 | 0.68 | RHEB (0.48) | RHEBDHFRALDH1A1MAPTRORC | |
| SCHEMBL7971117 | 0.67 | MAOA (0.58) | ALDH1A1MAPTL3MBTL1HTTKDM4E | |
| SCHEMBL19865517 | 0.67 | NQO2 (0.42) | ALDH1A1MAPTKDM4EMEN1HPGD | |
| SCHEMBL6606799 | 0.66 | BRPF1 (0.51) | ALDH1A1MAPTHTTGAAKDM4E | |
| SCHEMBL18271426 | 0.65 | MAPT (0.44) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL23709579 | 0.65 | RHEB (0.76) | RHEBALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL12527325 | 0.65 | RHEB (0.58) | RHEBALDH1A1MAPTRORCASH1L | |
| SCHEMBL27228197 | 0.65 | CCR4 (0.44) | EP300ALDH1A1S100BMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304046-B2 | Phosphoramide compounds | PURDUE RESEARCH FOUNDATION (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304046-B2 | Phosphoramide compounds | PURDUE RESEARCH FOUNDATION (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304046-B2 | Phosphoramide compounds | PURDUE RESEARCH FOUNDATION (US) | 2007-12-04 | — | — | US | disclosed |
| US-20040176332-A1 | Phosphoramide compounds | PURDUE RESEARCH FOUNDATION | 2004-09-09 | — | — | US | disclosed |
| US-6656926-B2 | For therapy and prophylaxis of cancer | PURDUE RESEARCH FOUNDATION | 2003-12-02 | — | — | US | disclosed |
| US-20030008850-A1 | For therapy and prophylaxis of cancer | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176332-A1 | Phosphoramide compounds | RB1, RRM2B, RRM1 | RHEB 352/4885EP300 2246/4885DHFR 680/4885 |
| US-20030008850-A1 | For therapy and prophylaxis of cancer | BRCA1, RRM2B, FOLR1 | RHEB 348/4885EP300 2570/4885DHFR 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.